Sulfa drugs strike more than once

Onisha G. Patel; Eddy K. Mberu; Alexis M. Nzila; Ian G. Macreadie

doi:10.1016/j.pt.2003.10.009

Sulfa drugs strike more than once

Onisha G. Patel
, Eddy K. Mberu
, Alexis M. Nzila
, Ian G. Macreadie^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

48 Scopus citations

Abstract

Sulfa drugs are well known blockers of folate synthesis, acting as competitive inhibitors of p-aminobenzoate (pABA). Their mimicry of pABA is so complete that they can also condense with 2-amino-4-hydroxy-6-hydroxymethyl-7,8 dihydropteridine pyrophosphate to form sulfa-dihydropteroate (sulfa-DHP), which are inhibitory through competition with dihydrofolate. This suggests that, in addition to dihydropteroate synthase, there are still undiscovered determinants involved in sulfa drug resistance. Furthermore, novel drugs based on the DHP analogues could be added to the armory of antifolate drugs.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Trends in Parasitology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.pt.2003.10.009
State	Published - Jan 2004
Externally published	Yes

Bibliographical note

Funding Information:
We thank Lindsay Sparrow and Ross Fernley for their critical reading of this manuscript. A.N. and E.M. thank The Wellcome Trust of Great Britain for financial support (ref. no. 056769).

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/j.pt.2003.10.009

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title = "Sulfa drugs strike more than once",

abstract = "Sulfa drugs are well known blockers of folate synthesis, acting as competitive inhibitors of p-aminobenzoate (pABA). Their mimicry of pABA is so complete that they can also condense with 2-amino-4-hydroxy-6-hydroxymethyl-7,8 dihydropteridine pyrophosphate to form sulfa-dihydropteroate (sulfa-DHP), which are inhibitory through competition with dihydrofolate. This suggests that, in addition to dihydropteroate synthase, there are still undiscovered determinants involved in sulfa drug resistance. Furthermore, novel drugs based on the DHP analogues could be added to the armory of antifolate drugs.",

author = "Patel, \{Onisha G.\} and Mberu, \{Eddy K.\} and Nzila, \{Alexis M.\} and Macreadie, \{Ian G.\}",

note = "Funding Information: We thank Lindsay Sparrow and Ross Fernley for their critical reading of this manuscript. A.N. and E.M. thank The Wellcome Trust of Great Britain for financial support (ref. no. 056769).",

year = "2004",

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doi = "10.1016/j.pt.2003.10.009",

language = "English",

volume = "20",

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T1 - Sulfa drugs strike more than once

AU - Patel, Onisha G.

AU - Mberu, Eddy K.

AU - Nzila, Alexis M.

AU - Macreadie, Ian G.

N1 - Funding Information: We thank Lindsay Sparrow and Ross Fernley for their critical reading of this manuscript. A.N. and E.M. thank The Wellcome Trust of Great Britain for financial support (ref. no. 056769).

PY - 2004/1

Y1 - 2004/1

N2 - Sulfa drugs are well known blockers of folate synthesis, acting as competitive inhibitors of p-aminobenzoate (pABA). Their mimicry of pABA is so complete that they can also condense with 2-amino-4-hydroxy-6-hydroxymethyl-7,8 dihydropteridine pyrophosphate to form sulfa-dihydropteroate (sulfa-DHP), which are inhibitory through competition with dihydrofolate. This suggests that, in addition to dihydropteroate synthase, there are still undiscovered determinants involved in sulfa drug resistance. Furthermore, novel drugs based on the DHP analogues could be added to the armory of antifolate drugs.

AB - Sulfa drugs are well known blockers of folate synthesis, acting as competitive inhibitors of p-aminobenzoate (pABA). Their mimicry of pABA is so complete that they can also condense with 2-amino-4-hydroxy-6-hydroxymethyl-7,8 dihydropteridine pyrophosphate to form sulfa-dihydropteroate (sulfa-DHP), which are inhibitory through competition with dihydrofolate. This suggests that, in addition to dihydropteroate synthase, there are still undiscovered determinants involved in sulfa drug resistance. Furthermore, novel drugs based on the DHP analogues could be added to the armory of antifolate drugs.

UR - https://www.scopus.com/pages/publications/0347059409

U2 - 10.1016/j.pt.2003.10.009

DO - 10.1016/j.pt.2003.10.009

M3 - Short survey

C2 - 14700578

AN - SCOPUS:0347059409

SN - 1471-4922

VL - 20

SP - 1

EP - 3

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 1

ER -

Sulfa drugs strike more than once

Abstract

Bibliographical note

ASJC Scopus subject areas

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