Substituted pyrazoles and their heteroannulated analogs—recent syntheses and biological activities

Mohamed Ramadan; Ashraf A. Aly; Lamiaa E.Abd El‐haleem; Mohammed B. Alshammari; Stefan Bräse

doi:10.3390/molecules26164995

Substituted pyrazoles and their heteroannulated analogs—recent syntheses and biological activities

Mohamed Ramadan, Ashraf A. Aly^*, Lamiaa E.Abd El‐haleem, Mohammed B. Alshammari, Stefan Bräse^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives. Therefore, we focused our attention on recent topics, up until 2020, for the synthesis of pyrazoles, their heteroannulated deriva-tives, and their applications as biologically active moieties. Moreover, we focused on traditional procedures used in the synthesis of pyrazoles.

Original language	English
Article number	4995
Journal	Molecules
Volume	26
Issue number	16
DOIs	https://doi.org/10.3390/molecules26164995
State	Published - Aug 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Biological activity
Heteroannulated
Pyrazole
Reactions
Synthesis

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Substituted pyrazoles and their heteroannulated analogs—recent syntheses and biological activities",

abstract = "Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives. Therefore, we focused our attention on recent topics, up until 2020, for the synthesis of pyrazoles, their heteroannulated deriva-tives, and their applications as biologically active moieties. Moreover, we focused on traditional procedures used in the synthesis of pyrazoles.",

keywords = "Biological activity, Heteroannulated, Pyrazole, Reactions, Synthesis",

author = "Mohamed Ramadan and Aly, \{Ashraf A.\} and El‐haleem, \{Lamiaa E.Abd\} and Alshammari, \{Mohammed B.\} and Stefan Br{\"a}se",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = aug,

doi = "10.3390/molecules26164995",

language = "English",

volume = "26",

journal = "Molecules",

issn = "1420-3049",

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AU - Ramadan, Mohamed

AU - Aly, Ashraf A.

AU - El‐haleem, Lamiaa E.Abd

AU - Alshammari, Mohammed B.

AU - Bräse, Stefan

PY - 2021/8

Y1 - 2021/8

N2 - Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives. Therefore, we focused our attention on recent topics, up until 2020, for the synthesis of pyrazoles, their heteroannulated deriva-tives, and their applications as biologically active moieties. Moreover, we focused on traditional procedures used in the synthesis of pyrazoles.

AB - Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives. Therefore, we focused our attention on recent topics, up until 2020, for the synthesis of pyrazoles, their heteroannulated deriva-tives, and their applications as biologically active moieties. Moreover, we focused on traditional procedures used in the synthesis of pyrazoles.

KW - Biological activity

KW - Heteroannulated

KW - Pyrazole

KW - Reactions

KW - Synthesis

UR - https://www.scopus.com/pages/publications/85113302995

U2 - 10.3390/molecules26164995

DO - 10.3390/molecules26164995

M3 - Review article

C2 - 34443583

AN - SCOPUS:85113302995

SN - 1420-3049

VL - 26

JO - Molecules

JF - Molecules

IS - 16

M1 - 4995

ER -

Substituted pyrazoles and their heteroannulated analogs—recent syntheses and biological activities

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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