Studies on the interaction of gold(I) thiomalate ('myochrysine') with 2-thiouracil in aqueous solution followed by 13C NMR spectroscopy

Anvarhusein A. Isab

doi:10.1016/S0020-1693(00)91457-9

Studies on the interaction of gold(I) thiomalate ('myochrysine') with 2-thiouracil in aqueous solution followed by ¹³C NMR spectroscopy

Anvarhusein A. Isab^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The interaction of gold(I) thiomalate (Autm) ('Myochrysine') with 2-thiouracil (2-TUH) has been studied in aqueous solution by ¹³C NMR spectroscopy. 2-TUH is in slow exchange at a 1:1 ratio of Autm:2-TU, but at higher ratios, fast exchange occurs with the tm^- of Autm. No free tm^-13C NMR resonances were observed. When L-cysteine and CN^- were added sequentially to the 1:3 ratio of Autm:2-TU solution, the cysteine did not remove 2-TUH from the complexed 2-TU-Autm, however, CN^- bound strongly to Au(I) forming Au(CN)₂^- and released 2-TUH and tm^- as free ligands.

Original language	English
Pages (from-to)	73-77
Number of pages	5
Journal	Inorganica Chimica Acta
Volume	207
Issue number	1
DOIs	https://doi.org/10.1016/S0020-1693(00)91457-9
State	Published - 1 May 1993

Bibliographical note

Funding Information:
This researchw ass upportedb y the KFUPM Research Committee under project no. CY/DRUG/124.

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/S0020-1693(00)91457-9

Cite this

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title = "Studies on the interaction of gold(I) thiomalate ('myochrysine') with 2-thiouracil in aqueous solution followed by 13C NMR spectroscopy",

abstract = "The interaction of gold(I) thiomalate (Autm) ('Myochrysine') with 2-thiouracil (2-TUH) has been studied in aqueous solution by 13C NMR spectroscopy. 2-TUH is in slow exchange at a 1:1 ratio of Autm:2-TU, but at higher ratios, fast exchange occurs with the tm- of Autm. No free tm-13C NMR resonances were observed. When L-cysteine and CN- were added sequentially to the 1:3 ratio of Autm:2-TU solution, the cysteine did not remove 2-TUH from the complexed 2-TU-Autm, however, CN- bound strongly to Au(I) forming Au(CN)2- and released 2-TUH and tm- as free ligands.",

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N2 - The interaction of gold(I) thiomalate (Autm) ('Myochrysine') with 2-thiouracil (2-TUH) has been studied in aqueous solution by 13C NMR spectroscopy. 2-TUH is in slow exchange at a 1:1 ratio of Autm:2-TU, but at higher ratios, fast exchange occurs with the tm- of Autm. No free tm-13C NMR resonances were observed. When L-cysteine and CN- were added sequentially to the 1:3 ratio of Autm:2-TU solution, the cysteine did not remove 2-TUH from the complexed 2-TU-Autm, however, CN- bound strongly to Au(I) forming Au(CN)2- and released 2-TUH and tm- as free ligands.

AB - The interaction of gold(I) thiomalate (Autm) ('Myochrysine') with 2-thiouracil (2-TUH) has been studied in aqueous solution by 13C NMR spectroscopy. 2-TUH is in slow exchange at a 1:1 ratio of Autm:2-TU, but at higher ratios, fast exchange occurs with the tm- of Autm. No free tm-13C NMR resonances were observed. When L-cysteine and CN- were added sequentially to the 1:3 ratio of Autm:2-TU solution, the cysteine did not remove 2-TUH from the complexed 2-TU-Autm, however, CN- bound strongly to Au(I) forming Au(CN)2- and released 2-TUH and tm- as free ligands.

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