Structure, magnetoelectric, and anticancer activities of core-shell Co0·8Mn0.2R0.02Fe1·98O4@BaTiO3 nanocomposites (R = Ce, Eu, Tb, Tm, or Gd)

Tahani M. Alfareed; Yassine Slimani; Munirah A. Almessiere; Sagar E. Shirsath; M. Hassan; Muhammad Nawaz; Firdos A. Khan; Ebtesam A. Al-Suhaimi; Abdulhadi Baykal

doi:10.1016/j.ceramint.2022.01.358

Structure, magnetoelectric, and anticancer activities of core-shell Co₀_·₈Mn_0.2R_0.02Fe₁_·₉₈O₄@BaTiO₃ nanocomposites (R = Ce, Eu, Tb, Tm, or Gd)

Tahani M. Alfareed, Yassine Slimani, Munirah A. Almessiere^*, Sagar E. Shirsath, M. Hassan, Muhammad Nawaz, Firdos A. Khan, Ebtesam A. Al-Suhaimi, Abdulhadi Baykal

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

In the present study, Co₀_·₈Mn_0.2R_0.02Fe₁_·₉₈O₄ (CoMnRFe) (R = Ce, Eu, Tb, Tm, or Gd) nanoparticles (NPs) have been prepared and coated with BaTiO₃ (BTO) using sonochemical and sol-gel methods to form various core-shell CoMnRFe@BTO magnetoelectric nanoparticles (MENs). The structure and morphologies of CoMnRFe@BTO MENs were assessed by XRD, SEM, TEM, HRTEM, EDX, XPS, and zeta potential techniques. The formation of core-shell CoMnRFe@BTO MENs was approved by XRD and HRTEM. SEM analysis of core-shell MENs revealed aggregation of spherical grains. The impact of CoMnRFe NPs and CoMnRFe@BTO MENs on human colon cancer cells (HCT-116) were examined and compared to normal non-cancerous cells (HEK-293) by using MTT assay and DAPI staining. After 48 h of treatment, it was found that CoMnRFe NPs showed a significant inhibitory effect on HCT-116 cells. Also, HEK-293 cells showed inhibitory action, but the percentage of cells viability was higher than HCT-116 cells. When HCT-116 cells are treated with CoMnRFe@BTO MENs, it showed a better cytotoxic effect compared to HEK-293 cells. In addition, CoMnRFe NPs and CoMnRFe@BTO MENs induced apoptotic cell death as revealed by DAPI staining. Our results suggest that CoMnRFe NPs and CoMnRFe@BTO MENs possess anti-colon cancer capabilities, but CoMnRFe@BTO MENs are safe materials as they do not cause any significant cytotoxic effect on HEK-293 cells compared to CoMnRFe NPs.

Original language	English
Pages (from-to)	14640-14651
Number of pages	12
Journal	Ceramics International
Volume	48
Issue number	10
DOIs	https://doi.org/10.1016/j.ceramint.2022.01.358
State	Published - 15 May 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Ltd and Techna Group S.r.l.

Keywords

Anti-Cancer activity
Colon cancer
Magnetoelectric nanoparticles
Morphology
Sonochemical and sol-gel methods
Structure

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Process Chemistry and Technology
Surfaces, Coatings and Films
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ceramint.2022.01.358

Cite this

Alfareed, T. M., Slimani, Y., Almessiere, M. A., Shirsath, S. E., Hassan, M., Nawaz, M., Khan, F. A., Al-Suhaimi, E. A., & Baykal, A. (2022). Structure, magnetoelectric, and anticancer activities of core-shell Co₀_·₈Mn_0.2R_0.02Fe₁_·₉₈O₄@BaTiO₃ nanocomposites (R = Ce, Eu, Tb, Tm, or Gd). Ceramics International, 48(10), 14640-14651. https://doi.org/10.1016/j.ceramint.2022.01.358

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title = "Structure, magnetoelectric, and anticancer activities of core-shell Co0·8Mn0.2R0.02Fe1·98O4@BaTiO3 nanocomposites (R = Ce, Eu, Tb, Tm, or Gd)",

abstract = "In the present study, Co0·8Mn0.2R0.02Fe1·98O4 (CoMnRFe) (R = Ce, Eu, Tb, Tm, or Gd) nanoparticles (NPs) have been prepared and coated with BaTiO3 (BTO) using sonochemical and sol-gel methods to form various core-shell CoMnRFe@BTO magnetoelectric nanoparticles (MENs). The structure and morphologies of CoMnRFe@BTO MENs were assessed by XRD, SEM, TEM, HRTEM, EDX, XPS, and zeta potential techniques. The formation of core-shell CoMnRFe@BTO MENs was approved by XRD and HRTEM. SEM analysis of core-shell MENs revealed aggregation of spherical grains. The impact of CoMnRFe NPs and CoMnRFe@BTO MENs on human colon cancer cells (HCT-116) were examined and compared to normal non-cancerous cells (HEK-293) by using MTT assay and DAPI staining. After 48 h of treatment, it was found that CoMnRFe NPs showed a significant inhibitory effect on HCT-116 cells. Also, HEK-293 cells showed inhibitory action, but the percentage of cells viability was higher than HCT-116 cells. When HCT-116 cells are treated with CoMnRFe@BTO MENs, it showed a better cytotoxic effect compared to HEK-293 cells. In addition, CoMnRFe NPs and CoMnRFe@BTO MENs induced apoptotic cell death as revealed by DAPI staining. Our results suggest that CoMnRFe NPs and CoMnRFe@BTO MENs possess anti-colon cancer capabilities, but CoMnRFe@BTO MENs are safe materials as they do not cause any significant cytotoxic effect on HEK-293 cells compared to CoMnRFe NPs.",

keywords = "Anti-Cancer activity, Colon cancer, Magnetoelectric nanoparticles, Morphology, Sonochemical and sol-gel methods, Structure",

author = "Alfareed, \{Tahani M.\} and Yassine Slimani and Almessiere, \{Munirah A.\} and Shirsath, \{Sagar E.\} and M. Hassan and Muhammad Nawaz and Khan, \{Firdos A.\} and Al-Suhaimi, \{Ebtesam A.\} and Abdulhadi Baykal",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd and Techna Group S.r.l.",

year = "2022",

month = may,

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doi = "10.1016/j.ceramint.2022.01.358",

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Alfareed, TM, Slimani, Y, Almessiere, MA, Shirsath, SE, Hassan, M, Nawaz, M, Khan, FA, Al-Suhaimi, EA & Baykal, A 2022, 'Structure, magnetoelectric, and anticancer activities of core-shell Co₀_·₈Mn_0.2R_0.02Fe₁_·₉₈O₄@BaTiO₃ nanocomposites (R = Ce, Eu, Tb, Tm, or Gd)', Ceramics International, vol. 48, no. 10, pp. 14640-14651. https://doi.org/10.1016/j.ceramint.2022.01.358

TY - JOUR

T1 - Structure, magnetoelectric, and anticancer activities of core-shell Co0·8Mn0.2R0.02Fe1·98O4@BaTiO3 nanocomposites (R = Ce, Eu, Tb, Tm, or Gd)

AU - Alfareed, Tahani M.

AU - Slimani, Yassine

AU - Almessiere, Munirah A.

AU - Shirsath, Sagar E.

AU - Hassan, M.

AU - Nawaz, Muhammad

AU - Khan, Firdos A.

AU - Al-Suhaimi, Ebtesam A.

AU - Baykal, Abdulhadi

PY - 2022/5/15

Y1 - 2022/5/15

N2 - In the present study, Co0·8Mn0.2R0.02Fe1·98O4 (CoMnRFe) (R = Ce, Eu, Tb, Tm, or Gd) nanoparticles (NPs) have been prepared and coated with BaTiO3 (BTO) using sonochemical and sol-gel methods to form various core-shell CoMnRFe@BTO magnetoelectric nanoparticles (MENs). The structure and morphologies of CoMnRFe@BTO MENs were assessed by XRD, SEM, TEM, HRTEM, EDX, XPS, and zeta potential techniques. The formation of core-shell CoMnRFe@BTO MENs was approved by XRD and HRTEM. SEM analysis of core-shell MENs revealed aggregation of spherical grains. The impact of CoMnRFe NPs and CoMnRFe@BTO MENs on human colon cancer cells (HCT-116) were examined and compared to normal non-cancerous cells (HEK-293) by using MTT assay and DAPI staining. After 48 h of treatment, it was found that CoMnRFe NPs showed a significant inhibitory effect on HCT-116 cells. Also, HEK-293 cells showed inhibitory action, but the percentage of cells viability was higher than HCT-116 cells. When HCT-116 cells are treated with CoMnRFe@BTO MENs, it showed a better cytotoxic effect compared to HEK-293 cells. In addition, CoMnRFe NPs and CoMnRFe@BTO MENs induced apoptotic cell death as revealed by DAPI staining. Our results suggest that CoMnRFe NPs and CoMnRFe@BTO MENs possess anti-colon cancer capabilities, but CoMnRFe@BTO MENs are safe materials as they do not cause any significant cytotoxic effect on HEK-293 cells compared to CoMnRFe NPs.

AB - In the present study, Co0·8Mn0.2R0.02Fe1·98O4 (CoMnRFe) (R = Ce, Eu, Tb, Tm, or Gd) nanoparticles (NPs) have been prepared and coated with BaTiO3 (BTO) using sonochemical and sol-gel methods to form various core-shell CoMnRFe@BTO magnetoelectric nanoparticles (MENs). The structure and morphologies of CoMnRFe@BTO MENs were assessed by XRD, SEM, TEM, HRTEM, EDX, XPS, and zeta potential techniques. The formation of core-shell CoMnRFe@BTO MENs was approved by XRD and HRTEM. SEM analysis of core-shell MENs revealed aggregation of spherical grains. The impact of CoMnRFe NPs and CoMnRFe@BTO MENs on human colon cancer cells (HCT-116) were examined and compared to normal non-cancerous cells (HEK-293) by using MTT assay and DAPI staining. After 48 h of treatment, it was found that CoMnRFe NPs showed a significant inhibitory effect on HCT-116 cells. Also, HEK-293 cells showed inhibitory action, but the percentage of cells viability was higher than HCT-116 cells. When HCT-116 cells are treated with CoMnRFe@BTO MENs, it showed a better cytotoxic effect compared to HEK-293 cells. In addition, CoMnRFe NPs and CoMnRFe@BTO MENs induced apoptotic cell death as revealed by DAPI staining. Our results suggest that CoMnRFe NPs and CoMnRFe@BTO MENs possess anti-colon cancer capabilities, but CoMnRFe@BTO MENs are safe materials as they do not cause any significant cytotoxic effect on HEK-293 cells compared to CoMnRFe NPs.

KW - Anti-Cancer activity

KW - Colon cancer

KW - Magnetoelectric nanoparticles

KW - Morphology

KW - Sonochemical and sol-gel methods

KW - Structure

UR - https://www.scopus.com/pages/publications/85124496383

U2 - 10.1016/j.ceramint.2022.01.358

DO - 10.1016/j.ceramint.2022.01.358

M3 - Article

AN - SCOPUS:85124496383

SN - 0272-8842

VL - 48

SP - 14640

EP - 14651

JO - Ceramics International

JF - Ceramics International

IS - 10

ER -