Stimuli-responsive polymers for the targeted delivery of paclitaxel to hepatocytes

Noreen T. Zaman; Yi Yan Yang; Jackie Y. Ying

doi:10.1016/j.nantod.2009.12.008

Stimuli-responsive polymers for the targeted delivery of paclitaxel to hepatocytes

Noreen T. Zaman, Yi Yan Yang, Jackie Y. Ying^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

This study presents a targeted and stimuli-responsive drug delivery system to increase the therapeutic window of chemotherapeutic agents. Galactose was expressed on an amphiphilic, temperature- and pH-sensitive copolymer of N-isopropylacrylamide, N,N-dimethylacrylamide and 10-undecenoic acid. The polymer would self-assemble in aqueous medium, and was used to encapsulate paclitaxel. Various synthesis parameters were examined to achieve polymers that provide high drug loading and rapid release in a temperature- and pH-responsive manner. In the target hepatocyte cell line, the stimuli-responsive, galactose-expressing particles were significantly more toxic than the non-stimuli-responsive particles as well as the non-targeted particles.

Original language	English
Pages (from-to)	9-14
Number of pages	6
Journal	Nano Today
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.nantod.2009.12.008
State	Published - Feb 2010
Externally published	Yes

Keywords

Galactose-targeting
Hepatocytes
Paclitaxel
Thermosensitive
pH-sensitive

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
General Materials Science
Pharmaceutical Science

Access to Document

10.1016/j.nantod.2009.12.008

Cite this

@article{c039e5d617594226aa28c38daeb50481,

title = "Stimuli-responsive polymers for the targeted delivery of paclitaxel to hepatocytes",

abstract = "This study presents a targeted and stimuli-responsive drug delivery system to increase the therapeutic window of chemotherapeutic agents. Galactose was expressed on an amphiphilic, temperature- and pH-sensitive copolymer of N-isopropylacrylamide, N,N-dimethylacrylamide and 10-undecenoic acid. The polymer would self-assemble in aqueous medium, and was used to encapsulate paclitaxel. Various synthesis parameters were examined to achieve polymers that provide high drug loading and rapid release in a temperature- and pH-responsive manner. In the target hepatocyte cell line, the stimuli-responsive, galactose-expressing particles were significantly more toxic than the non-stimuli-responsive particles as well as the non-targeted particles.",

keywords = "Galactose-targeting, Hepatocytes, Paclitaxel, Thermosensitive, pH-sensitive",

author = "Zaman, \{Noreen T.\} and Yang, \{Yi Yan\} and Ying, \{Jackie Y.\}",

year = "2010",

month = feb,

doi = "10.1016/j.nantod.2009.12.008",

language = "English",

volume = "5",

pages = "9--14",

journal = "Nano Today",

issn = "1748-0132",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Stimuli-responsive polymers for the targeted delivery of paclitaxel to hepatocytes

AU - Zaman, Noreen T.

AU - Yang, Yi Yan

AU - Ying, Jackie Y.

PY - 2010/2

Y1 - 2010/2

N2 - This study presents a targeted and stimuli-responsive drug delivery system to increase the therapeutic window of chemotherapeutic agents. Galactose was expressed on an amphiphilic, temperature- and pH-sensitive copolymer of N-isopropylacrylamide, N,N-dimethylacrylamide and 10-undecenoic acid. The polymer would self-assemble in aqueous medium, and was used to encapsulate paclitaxel. Various synthesis parameters were examined to achieve polymers that provide high drug loading and rapid release in a temperature- and pH-responsive manner. In the target hepatocyte cell line, the stimuli-responsive, galactose-expressing particles were significantly more toxic than the non-stimuli-responsive particles as well as the non-targeted particles.

AB - This study presents a targeted and stimuli-responsive drug delivery system to increase the therapeutic window of chemotherapeutic agents. Galactose was expressed on an amphiphilic, temperature- and pH-sensitive copolymer of N-isopropylacrylamide, N,N-dimethylacrylamide and 10-undecenoic acid. The polymer would self-assemble in aqueous medium, and was used to encapsulate paclitaxel. Various synthesis parameters were examined to achieve polymers that provide high drug loading and rapid release in a temperature- and pH-responsive manner. In the target hepatocyte cell line, the stimuli-responsive, galactose-expressing particles were significantly more toxic than the non-stimuli-responsive particles as well as the non-targeted particles.

KW - Galactose-targeting

KW - Hepatocytes

KW - Paclitaxel

KW - Thermosensitive

KW - pH-sensitive

UR - https://www.scopus.com/pages/publications/76749125296

U2 - 10.1016/j.nantod.2009.12.008

DO - 10.1016/j.nantod.2009.12.008

M3 - Article

AN - SCOPUS:76749125296

SN - 1748-0132

VL - 5

SP - 9

EP - 14

JO - Nano Today

JF - Nano Today

IS - 1

ER -

Stimuli-responsive polymers for the targeted delivery of paclitaxel to hepatocytes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this