Stimuli-Responsive Macromolecular Architecture by Butler Cyclopolymerizations: Synthesis and Applications

Shaikh A. Ali*, Hasan A. Al-Muallem, Mohammad A.J. Mazumder*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


This article reviews the synthesis of polyzwitterions (PZs) (poly-carboxybetaines, -phosphonobetaines, and -sulfobetaines) having multiple pH-responsive centers. The synthesis follows the Butler cyclopolymerization protocol involving a multitude of diallylammonium salts and their copolymerization with SO2 and maleic acid. The PZs have been transformed into cationic-, anionic-polyelectrolytes, and polyampholytes under the influence of pH. Particular attention is given to the application of these polymers as antiscalants, mild steel corrosion inhibitors, components in constructing Aqueous Two-Phase Systems (ATPSs), and membrane modifiers. The ATPSs could be used to separate various biomolecules, including proteins. Many amphiphilic polymers incorporating a few mol % hydrophobic monomers have shown enhanced viscosities and could be suitable for applications in oil fields. The progress of applying Butler cyclopolymerization in reversible addition-fragmentation chain transfer (RAFT) chemistry has been discussed. Future works are expected to focus on RAFT cyclopolymerization to construct block copolymers.

Original languageEnglish
Article numbere202200235
JournalChemical Record
Issue number2
StatePublished - Feb 2023

Bibliographical note

Publisher Copyright:
© 2022 The Chemical Society of Japan & Wiley-VCH GmbH.


  • Cyclopolymerization
  • antiscalants
  • carboxybetaine
  • corrosion inhibition
  • hydrophobic association
  • phosphonobetaine
  • polyampholyte
  • polyzwitterion
  • sulfobetaine

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry
  • General Chemical Engineering
  • Materials Chemistry


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