State feedback based intervention design in Wnt and cell cycle network

Aamer Iqbal Bhatti; Muhammad Haseeb; Shumaila Azam; Sahar Fazal; Mukhtar Ullah

doi:10.23919/ACC.2017.7963607

State feedback based intervention design in Wnt and cell cycle network

Aamer Iqbal Bhatti
, Muhammad Haseeb
, Shumaila Azam
, Sahar Fazal
, Mukhtar Ullah

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Recent studies have shown a strong link between the cell cycle and the canonical version of Wnt pathway. Based on these findings it can be safely speculated that Wnt pathway plays an important role in cell cycle regulation. Conversely, it has been shown that cell cycle contributes towards the triggering of Wnt pathway. A novel binary model of the cell cycle interacting with Wnt pathway is developed and a new framework for intervention design is devised by employing state feedback for binary systems. The intervention analysis and design approach is chosen such that potential of binary models is fully utilized and the framework devised should be rigorous and generic. For this purpose Semi Tensor Product (STP) approach is used. The designed intervention is tested through simulations. The simulation results depict validity and efficacy of the designed intervention even for different initial conditions.

Original language	English
Title of host publication	2017 American Control Conference, ACC 2017
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	4242-4247
Number of pages	6
ISBN (Electronic)	9781509059928
DOIs	https://doi.org/10.23919/ACC.2017.7963607
State	Published - 29 Jun 2017
Externally published	Yes

Publication series

Name	Proceedings of the American Control Conference
ISSN (Print)	0743-1619

Bibliographical note

Publisher Copyright:
© 2017 American Automatic Control Council (AACC).

Keywords

Cell Cycle
Intervention/Drug Design
Semi Tensor Product
Wnt pathway

ASJC Scopus subject areas

Electrical and Electronic Engineering

Access to Document

10.23919/ACC.2017.7963607

Cite this

@inproceedings{00ee20c001d444c6bbc247165af9eef4,

title = "State feedback based intervention design in Wnt and cell cycle network",

abstract = "Recent studies have shown a strong link between the cell cycle and the canonical version of Wnt pathway. Based on these findings it can be safely speculated that Wnt pathway plays an important role in cell cycle regulation. Conversely, it has been shown that cell cycle contributes towards the triggering of Wnt pathway. A novel binary model of the cell cycle interacting with Wnt pathway is developed and a new framework for intervention design is devised by employing state feedback for binary systems. The intervention analysis and design approach is chosen such that potential of binary models is fully utilized and the framework devised should be rigorous and generic. For this purpose Semi Tensor Product (STP) approach is used. The designed intervention is tested through simulations. The simulation results depict validity and efficacy of the designed intervention even for different initial conditions.",

keywords = "Cell Cycle, Intervention/Drug Design, Semi Tensor Product, Wnt pathway",

author = "Bhatti, \{Aamer Iqbal\} and Muhammad Haseeb and Shumaila Azam and Sahar Fazal and Mukhtar Ullah",

note = "Publisher Copyright: {\textcopyright} 2017 American Automatic Control Council (AACC).",

year = "2017",

month = jun,

day = "29",

doi = "10.23919/ACC.2017.7963607",

language = "English",

series = "Proceedings of the American Control Conference",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "4242--4247",

booktitle = "2017 American Control Conference, ACC 2017",

address = "United States",

}

State feedback based intervention design in Wnt and cell cycle network. / Bhatti, Aamer Iqbal; Haseeb, Muhammad; Azam, Shumaila et al.
2017 American Control Conference, ACC 2017. Institute of Electrical and Electronics Engineers Inc., 2017. p. 4242-4247 7963607 (Proceedings of the American Control Conference).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - State feedback based intervention design in Wnt and cell cycle network

AU - Bhatti, Aamer Iqbal

AU - Haseeb, Muhammad

AU - Azam, Shumaila

AU - Fazal, Sahar

AU - Ullah, Mukhtar

PY - 2017/6/29

Y1 - 2017/6/29

N2 - Recent studies have shown a strong link between the cell cycle and the canonical version of Wnt pathway. Based on these findings it can be safely speculated that Wnt pathway plays an important role in cell cycle regulation. Conversely, it has been shown that cell cycle contributes towards the triggering of Wnt pathway. A novel binary model of the cell cycle interacting with Wnt pathway is developed and a new framework for intervention design is devised by employing state feedback for binary systems. The intervention analysis and design approach is chosen such that potential of binary models is fully utilized and the framework devised should be rigorous and generic. For this purpose Semi Tensor Product (STP) approach is used. The designed intervention is tested through simulations. The simulation results depict validity and efficacy of the designed intervention even for different initial conditions.

AB - Recent studies have shown a strong link between the cell cycle and the canonical version of Wnt pathway. Based on these findings it can be safely speculated that Wnt pathway plays an important role in cell cycle regulation. Conversely, it has been shown that cell cycle contributes towards the triggering of Wnt pathway. A novel binary model of the cell cycle interacting with Wnt pathway is developed and a new framework for intervention design is devised by employing state feedback for binary systems. The intervention analysis and design approach is chosen such that potential of binary models is fully utilized and the framework devised should be rigorous and generic. For this purpose Semi Tensor Product (STP) approach is used. The designed intervention is tested through simulations. The simulation results depict validity and efficacy of the designed intervention even for different initial conditions.

KW - Cell Cycle

KW - Intervention/Drug Design

KW - Semi Tensor Product

KW - Wnt pathway

UR - https://www.scopus.com/pages/publications/85027034422

U2 - 10.23919/ACC.2017.7963607

DO - 10.23919/ACC.2017.7963607

M3 - Conference contribution

AN - SCOPUS:85027034422

T3 - Proceedings of the American Control Conference

SP - 4242

EP - 4247

BT - 2017 American Control Conference, ACC 2017

PB - Institute of Electrical and Electronics Engineers Inc.

ER -

State feedback based intervention design in Wnt and cell cycle network

Abstract

Publication series

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this