Solubility enhancement of simvastatin through development of hydroxypropyl beta-cyclodextrin based microparticulate system and its in vitro evaluation

Sajid Bashir; Rai M. Sarfraz; Husnain Ahmad; Muhammad R. Akram; Muhammad N. Qaisar; Muhammad R. Ali; Muhammad U. Khan

Solubility enhancement of simvastatin through development of hydroxypropyl beta-cyclodextrin based microparticulate system and its in vitro evaluation

Sajid Bashir, Rai M. Sarfraz^*, Husnain Ahmad, Muhammad R. Akram, Muhammad N. Qaisar, Muhammad R. Ali, Muhammad U. Khan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This study was performed to increase solubility of simvastatin by using solid dispersion method. In this technique polymer 3-hydroxy propyl beta-cyclodextrin (HPBCD) was used. Solid dispersion was formed by using solvent evaporation method. The FTIR-spectra of formulations confirmed the complex formation between simvastatin and HPBCD. The DSC (differential scanning calorimetry) and XRD (X-ray diffractometry) results showed no endothermic and characteristic peaks of simvastatin were noted. This study clearly revealed that change in crystalline nature of simvastatin to amorphous form. Re-lease kinetics, aqueous solubility, and dissolution profiles were greatly increased by this technique as compared to drug alone.

Original language	English
Pages (from-to)	1000-1008
Number of pages	9
Journal	Latin American Journal of Pharmacy
Volume	39
Issue number	5
State	Published - 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.

Keywords

Bioavailability
Simvastatin
Solid dispersion
Solubility
Solvent evaporation

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery

Cite this

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title = "Solubility enhancement of simvastatin through development of hydroxypropyl beta-cyclodextrin based microparticulate system and its in vitro evaluation",

abstract = "This study was performed to increase solubility of simvastatin by using solid dispersion method. In this technique polymer 3-hydroxy propyl beta-cyclodextrin (HPBCD) was used. Solid dispersion was formed by using solvent evaporation method. The FTIR-spectra of formulations confirmed the complex formation between simvastatin and HPBCD. The DSC (differential scanning calorimetry) and XRD (X-ray diffractometry) results showed no endothermic and characteristic peaks of simvastatin were noted. This study clearly revealed that change in crystalline nature of simvastatin to amorphous form. Re-lease kinetics, aqueous solubility, and dissolution profiles were greatly increased by this technique as compared to drug alone.",

keywords = "Bioavailability, Simvastatin, Solid dispersion, Solubility, Solvent evaporation",

author = "Sajid Bashir and Sarfraz, \{Rai M.\} and Husnain Ahmad and Akram, \{Muhammad R.\} and Qaisar, \{Muhammad N.\} and Ali, \{Muhammad R.\} and Khan, \{Muhammad U.\}",

year = "2020",

language = "English",

volume = "39",

pages = "1000--1008",

journal = "Latin American Journal of Pharmacy",

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TY - JOUR

T1 - Solubility enhancement of simvastatin through development of hydroxypropyl beta-cyclodextrin based microparticulate system and its in vitro evaluation

AU - Bashir, Sajid

AU - Sarfraz, Rai M.

AU - Ahmad, Husnain

AU - Akram, Muhammad R.

AU - Qaisar, Muhammad N.

AU - Ali, Muhammad R.

AU - Khan, Muhammad U.

PY - 2020

Y1 - 2020

N2 - This study was performed to increase solubility of simvastatin by using solid dispersion method. In this technique polymer 3-hydroxy propyl beta-cyclodextrin (HPBCD) was used. Solid dispersion was formed by using solvent evaporation method. The FTIR-spectra of formulations confirmed the complex formation between simvastatin and HPBCD. The DSC (differential scanning calorimetry) and XRD (X-ray diffractometry) results showed no endothermic and characteristic peaks of simvastatin were noted. This study clearly revealed that change in crystalline nature of simvastatin to amorphous form. Re-lease kinetics, aqueous solubility, and dissolution profiles were greatly increased by this technique as compared to drug alone.

AB - This study was performed to increase solubility of simvastatin by using solid dispersion method. In this technique polymer 3-hydroxy propyl beta-cyclodextrin (HPBCD) was used. Solid dispersion was formed by using solvent evaporation method. The FTIR-spectra of formulations confirmed the complex formation between simvastatin and HPBCD. The DSC (differential scanning calorimetry) and XRD (X-ray diffractometry) results showed no endothermic and characteristic peaks of simvastatin were noted. This study clearly revealed that change in crystalline nature of simvastatin to amorphous form. Re-lease kinetics, aqueous solubility, and dissolution profiles were greatly increased by this technique as compared to drug alone.

KW - Bioavailability

KW - Simvastatin

KW - Solid dispersion

KW - Solubility

KW - Solvent evaporation

UR - https://www.scopus.com/pages/publications/85084201995

M3 - Article

AN - SCOPUS:85084201995

SN - 0326-2383

VL - 39

SP - 1000

EP - 1008

JO - Latin American Journal of Pharmacy

JF - Latin American Journal of Pharmacy

IS - 5

ER -

Solubility enhancement of simvastatin through development of hydroxypropyl beta-cyclodextrin based microparticulate system and its in vitro evaluation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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