Solubility enhancement of rosuvastatin calcium through development of β-CD based microparticulate system and its in vitro evaluation

Present work is based upon the preparation of β-cyclodextrin based microparticulate systems through various techniques for solubility enhancement of rosuvastatin calcium. Two types of microparticulate system were prepared in the form of solid dispersion and hydrogel microparticles. Prepared formulations were characterized for entrapment efficiency and product yield, FTIR, DSC & TGA, PXRD, SEM, TEM, Zeta size and potential, solubility studies and in vitro drug release studies. Optimum drug release was observed for formulations S3 and HS7. A remarked improvement in solubility of rosuvastatin calcium was observed at pH 6.8. 10.66 folds enhancement in solubility was observed for hydrogel microparticles while solid dispersion system presented the 8.54 folds improvement in solubility. Results of in vitro studies presented the better release of drug from microparticulate systems as compared to commercially available tablets of RST. On the basis of these results β-cyclodextrin based microparticulate systems proved a potential tool for solubility enhancement of rosuvastatin calcium.