Sodium dodecyl sulphate-supported nanocomposite as drug carrier system for controlled delivery of ondansetron

Gaurav Sharma; Mu Naushad; Bharti Thakur; Amit Kumar; Poonam Negi; Reena Saini; Anterpreet Chahal; Ashok Kumar; Florian J. Stadler; U. M.H. Aqil

doi:10.3390/ijerph15030414

Sodium dodecyl sulphate-supported nanocomposite as drug carrier system for controlled delivery of ondansetron

Gaurav Sharma^*
, Mu Naushad
, Bharti Thakur
, Amit Kumar
, Poonam Negi
, Reena Saini
, Anterpreet Chahal
, Ashok Kumar
, Florian J. Stadler
, U. M.H. Aqil

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Sodium dodecyl sulphate-supported iron silicophosphate (SDS/FeSP) nanocomposite was successfully fabricated by the co-precipitation method. The SDS/FeSP nanocomposite was investigated as a drug carrier for ondansetron. The cumulative drug release of ondansetron was observed at various pH values for different time intervals, i.e., from 20 min to 48 h. A ranking of the drug release was observed at different pHs; pH 2.2 > saline (pH 5.5) > pH 7.4 > pH 9.4 > distilled water. Maximum release of encapsulated drug was found to be about 45.38% at pH 2.2. The cell viability tests of SDS/FeSP nanocomposite concluded that SDS/FeSP nanocomposite was non-cytotoxic in nature.

Original language	English
Article number	414
Journal	International Journal of Environmental Research and Public Health
Volume	15
Issue number	3
DOIs	https://doi.org/10.3390/ijerph15030414
State	Published - Mar 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Drug delivery
Nanocomposite
Ondansetron
Sodium dodecyl sulphate

ASJC Scopus subject areas

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.3390/ijerph15030414

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title = "Sodium dodecyl sulphate-supported nanocomposite as drug carrier system for controlled delivery of ondansetron",

abstract = "Sodium dodecyl sulphate-supported iron silicophosphate (SDS/FeSP) nanocomposite was successfully fabricated by the co-precipitation method. The SDS/FeSP nanocomposite was investigated as a drug carrier for ondansetron. The cumulative drug release of ondansetron was observed at various pH values for different time intervals, i.e., from 20 min to 48 h. A ranking of the drug release was observed at different pHs; pH 2.2 > saline (pH 5.5) > pH 7.4 > pH 9.4 > distilled water. Maximum release of encapsulated drug was found to be about 45.38\% at pH 2.2. The cell viability tests of SDS/FeSP nanocomposite concluded that SDS/FeSP nanocomposite was non-cytotoxic in nature.",

keywords = "Drug delivery, Nanocomposite, Ondansetron, Sodium dodecyl sulphate",

author = "Gaurav Sharma and Mu Naushad and Bharti Thakur and Amit Kumar and Poonam Negi and Reena Saini and Anterpreet Chahal and Ashok Kumar and Stadler, \{Florian J.\} and Aqil, \{U. M.H.\}",

note = "Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2018",

month = mar,

doi = "10.3390/ijerph15030414",

language = "English",

volume = "15",

journal = "International Journal of Environmental Research and Public Health",

issn = "1661-7827",

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T1 - Sodium dodecyl sulphate-supported nanocomposite as drug carrier system for controlled delivery of ondansetron

AU - Sharma, Gaurav

AU - Naushad, Mu

AU - Thakur, Bharti

AU - Kumar, Amit

AU - Negi, Poonam

AU - Saini, Reena

AU - Chahal, Anterpreet

AU - Kumar, Ashok

AU - Stadler, Florian J.

AU - Aqil, U. M.H.

PY - 2018/3

Y1 - 2018/3

N2 - Sodium dodecyl sulphate-supported iron silicophosphate (SDS/FeSP) nanocomposite was successfully fabricated by the co-precipitation method. The SDS/FeSP nanocomposite was investigated as a drug carrier for ondansetron. The cumulative drug release of ondansetron was observed at various pH values for different time intervals, i.e., from 20 min to 48 h. A ranking of the drug release was observed at different pHs; pH 2.2 > saline (pH 5.5) > pH 7.4 > pH 9.4 > distilled water. Maximum release of encapsulated drug was found to be about 45.38% at pH 2.2. The cell viability tests of SDS/FeSP nanocomposite concluded that SDS/FeSP nanocomposite was non-cytotoxic in nature.

AB - Sodium dodecyl sulphate-supported iron silicophosphate (SDS/FeSP) nanocomposite was successfully fabricated by the co-precipitation method. The SDS/FeSP nanocomposite was investigated as a drug carrier for ondansetron. The cumulative drug release of ondansetron was observed at various pH values for different time intervals, i.e., from 20 min to 48 h. A ranking of the drug release was observed at different pHs; pH 2.2 > saline (pH 5.5) > pH 7.4 > pH 9.4 > distilled water. Maximum release of encapsulated drug was found to be about 45.38% at pH 2.2. The cell viability tests of SDS/FeSP nanocomposite concluded that SDS/FeSP nanocomposite was non-cytotoxic in nature.

KW - Drug delivery

KW - Nanocomposite

KW - Ondansetron

KW - Sodium dodecyl sulphate

UR - https://www.scopus.com/pages/publications/85042793059

U2 - 10.3390/ijerph15030414

DO - 10.3390/ijerph15030414

M3 - Article

C2 - 29495530

AN - SCOPUS:85042793059

SN - 1661-7827

VL - 15

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

IS - 3

M1 - 414

ER -

Sodium dodecyl sulphate-supported nanocomposite as drug carrier system for controlled delivery of ondansetron

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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