TY - GEN
T1 - Sodium channels' kinetics under self-gating condition at neuromuscular junction
AU - Rahman, M. Mostafizur
AU - Mahmud, Mufti
AU - Vassanelli, Stefano
PY - 2011
Y1 - 2011
N2 - The neuromuscular junction (NMJ) is the synapse between the axon terminal of motoneuron and the 'endplate' of a muscle fiber. The nerve impulse leads to a large depolarization called the endplate potential, which in turn opens a large number of voltage-sensitive sodium channels located within post-junctional synaptic folds. This set off causing an 'all or nothing' action potential that is propagated along the muscle fiber and initiate muscle contraction. In this work we have simulated the behavior of the voltage-dependent sodium conductance within the NMJ using a mathematical model. We simulated sodium channels activation and inactivation kinetics under voltage clamp condition. We observed a self-gating behavior of the sodium conductance during activation and inactivation. The simulation results showed that self-gating of sodium channels increase conduction efficiency at the NMJ.
AB - The neuromuscular junction (NMJ) is the synapse between the axon terminal of motoneuron and the 'endplate' of a muscle fiber. The nerve impulse leads to a large depolarization called the endplate potential, which in turn opens a large number of voltage-sensitive sodium channels located within post-junctional synaptic folds. This set off causing an 'all or nothing' action potential that is propagated along the muscle fiber and initiate muscle contraction. In this work we have simulated the behavior of the voltage-dependent sodium conductance within the NMJ using a mathematical model. We simulated sodium channels activation and inactivation kinetics under voltage clamp condition. We observed a self-gating behavior of the sodium conductance during activation and inactivation. The simulation results showed that self-gating of sodium channels increase conduction efficiency at the NMJ.
KW - Activation of sodium channels
KW - Inactivation of sodium channels
KW - Self-gating
KW - Sodium channel kinetics
UR - https://www.scopus.com/pages/publications/84855766371
U2 - 10.1109/BMEI.2011.6098478
DO - 10.1109/BMEI.2011.6098478
M3 - Conference contribution
AN - SCOPUS:84855766371
SN - 9781424493524
T3 - Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
SP - 990
EP - 994
BT - Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
T2 - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
Y2 - 15 October 2011 through 17 October 2011
ER -