Simultaneous determination of pyridoxine hydrochloride and meclizine hydrochloride in tablet formulations by HPLC

T. Al-Jallad; Z. Al-Kurdi; A. Badwan; A. M.Y. Jaber

doi:10.1211/146080899128735199

Simultaneous determination of pyridoxine hydrochloride and meclizine hydrochloride in tablet formulations by HPLC

T. Al-Jallad
, Z. Al-Kurdi
, A. Badwan
, A. M.Y. Jaber^*

^*Corresponding author for this work

King Fahd University of Petroleum & Minerals

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A method for the simultaneous determination of pyridoxine hydrochloride and meclizine hydrochloride in Vominore tablets using HPLC is described. The mobile phase consisted of dodecyl sulphate sodium salt dissolved in a mixture of water, acetonitrile, methanol, glacial acetic acid and tetrahydrofuran. A Symmetry C₁₈ silica column (250 x 4.6 mm) gave the best resolution with minimal tailing factors. The method was suitable for the analysis of the two components in tablet dosage forms and as a stability indicating method. Matrix components did not interfere with the HPLC chromatograms of the two active ingredients. The method was accurate, repeatable and reproducible. The percentage recovery, bias and relative standard deviations for the HPLC measurements were within US Pharmacopeial limits.

Original language	English
Pages (from-to)	479-483
Number of pages	5
Journal	Pharmacy and Pharmacology Communications
Volume	5
Issue number	8
DOIs	https://doi.org/10.1211/146080899128735199
State	Published - Aug 1999

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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title = "Simultaneous determination of pyridoxine hydrochloride and meclizine hydrochloride in tablet formulations by HPLC",

abstract = "A method for the simultaneous determination of pyridoxine hydrochloride and meclizine hydrochloride in Vominore tablets using HPLC is described. The mobile phase consisted of dodecyl sulphate sodium salt dissolved in a mixture of water, acetonitrile, methanol, glacial acetic acid and tetrahydrofuran. A Symmetry C18 silica column (250 x 4.6 mm) gave the best resolution with minimal tailing factors. The method was suitable for the analysis of the two components in tablet dosage forms and as a stability indicating method. Matrix components did not interfere with the HPLC chromatograms of the two active ingredients. The method was accurate, repeatable and reproducible. The percentage recovery, bias and relative standard deviations for the HPLC measurements were within US Pharmacopeial limits.",

author = "T. Al-Jallad and Z. Al-Kurdi and A. Badwan and Jaber, \{A. M.Y.\}",

year = "1999",

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doi = "10.1211/146080899128735199",

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pages = "479--483",

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TY - JOUR

T1 - Simultaneous determination of pyridoxine hydrochloride and meclizine hydrochloride in tablet formulations by HPLC

AU - Al-Jallad, T.

AU - Al-Kurdi, Z.

AU - Badwan, A.

AU - Jaber, A. M.Y.

PY - 1999/8

Y1 - 1999/8

N2 - A method for the simultaneous determination of pyridoxine hydrochloride and meclizine hydrochloride in Vominore tablets using HPLC is described. The mobile phase consisted of dodecyl sulphate sodium salt dissolved in a mixture of water, acetonitrile, methanol, glacial acetic acid and tetrahydrofuran. A Symmetry C18 silica column (250 x 4.6 mm) gave the best resolution with minimal tailing factors. The method was suitable for the analysis of the two components in tablet dosage forms and as a stability indicating method. Matrix components did not interfere with the HPLC chromatograms of the two active ingredients. The method was accurate, repeatable and reproducible. The percentage recovery, bias and relative standard deviations for the HPLC measurements were within US Pharmacopeial limits.

AB - A method for the simultaneous determination of pyridoxine hydrochloride and meclizine hydrochloride in Vominore tablets using HPLC is described. The mobile phase consisted of dodecyl sulphate sodium salt dissolved in a mixture of water, acetonitrile, methanol, glacial acetic acid and tetrahydrofuran. A Symmetry C18 silica column (250 x 4.6 mm) gave the best resolution with minimal tailing factors. The method was suitable for the analysis of the two components in tablet dosage forms and as a stability indicating method. Matrix components did not interfere with the HPLC chromatograms of the two active ingredients. The method was accurate, repeatable and reproducible. The percentage recovery, bias and relative standard deviations for the HPLC measurements were within US Pharmacopeial limits.

UR - https://www.scopus.com/pages/publications/0032871408

U2 - 10.1211/146080899128735199

DO - 10.1211/146080899128735199

M3 - Article

AN - SCOPUS:0032871408

SN - 1460-8081

VL - 5

SP - 479

EP - 483

JO - Pharmacy and Pharmacology Communications

JF - Pharmacy and Pharmacology Communications

IS - 8

ER -

Simultaneous determination of pyridoxine hydrochloride and meclizine hydrochloride in tablet formulations by HPLC

Abstract

ASJC Scopus subject areas

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