Self-gating of sodium channels at neuromuscular junction

M. Mostafizur Rahman; Mufti Mahmud; Stefano Vassanelli

doi:10.1109/NER.2011.5910524

Self-gating of sodium channels at neuromuscular junction

M. Mostafizur Rahman
, Mufti Mahmud
, Stefano Vassanelli^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

The Neuromuscular Junction (NMJ) is the place where one end plate terminal of a motor neuron forms a synapse with a muscle fiber. Unlike synapses between neurons, the NMJ is characterized by a large number of voltage-dependent sodium channels located within post-junctional folds of the muscle fiber membrane. In this work we have used a mathematical model to simulate the behavior of the voltage-dependent sodium conductance within the NMJ. Simulations were restricted to sodium channels activation while inactivation was not considered. We observed a self-gating behavior of the sodium conductance, characterized by bistability and hysteresis. According to these results, self-gating of sodium channels in post-junctional folds could contribute to enhance transmission efficiency at the NMJ.

Original language	English
Title of host publication	2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
Pages	208-211
Number of pages	4
DOIs	https://doi.org/10.1109/NER.2011.5910524
State	Published - 2011
Externally published	Yes
Event	2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011 - Cancun, Mexico Duration: 27 Apr 2011 → 1 May 2011

Publication series

Name	2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011

Conference

Conference	2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
Country/Territory	Mexico
City	Cancun
Period	27/04/11 → 1/05/11

Keywords

Activation of sodium channels
Self-gating

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1109/NER.2011.5910524

Cite this

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title = "Self-gating of sodium channels at neuromuscular junction",

abstract = "The Neuromuscular Junction (NMJ) is the place where one end plate terminal of a motor neuron forms a synapse with a muscle fiber. Unlike synapses between neurons, the NMJ is characterized by a large number of voltage-dependent sodium channels located within post-junctional folds of the muscle fiber membrane. In this work we have used a mathematical model to simulate the behavior of the voltage-dependent sodium conductance within the NMJ. Simulations were restricted to sodium channels activation while inactivation was not considered. We observed a self-gating behavior of the sodium conductance, characterized by bistability and hysteresis. According to these results, self-gating of sodium channels in post-junctional folds could contribute to enhance transmission efficiency at the NMJ.",

keywords = "Activation of sodium channels, Self-gating",

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year = "2011",

doi = "10.1109/NER.2011.5910524",

language = "English",

isbn = "9781424441402",

series = "2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011",

pages = "208--211",

booktitle = "2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011",

note = "2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011 ; Conference date: 27-04-2011 Through 01-05-2011",

}

Rahman, MM, Mahmud, M & Vassanelli, S 2011, Self-gating of sodium channels at neuromuscular junction. in 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011., 5910524, 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011, pp. 208-211, 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011, Cancun, Mexico, 27/04/11. https://doi.org/10.1109/NER.2011.5910524

Self-gating of sodium channels at neuromuscular junction. / Rahman, M. Mostafizur; Mahmud, Mufti; Vassanelli, Stefano.
2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011. 2011. p. 208-211 5910524 (2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Self-gating of sodium channels at neuromuscular junction

AU - Rahman, M. Mostafizur

AU - Mahmud, Mufti

AU - Vassanelli, Stefano

PY - 2011

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N2 - The Neuromuscular Junction (NMJ) is the place where one end plate terminal of a motor neuron forms a synapse with a muscle fiber. Unlike synapses between neurons, the NMJ is characterized by a large number of voltage-dependent sodium channels located within post-junctional folds of the muscle fiber membrane. In this work we have used a mathematical model to simulate the behavior of the voltage-dependent sodium conductance within the NMJ. Simulations were restricted to sodium channels activation while inactivation was not considered. We observed a self-gating behavior of the sodium conductance, characterized by bistability and hysteresis. According to these results, self-gating of sodium channels in post-junctional folds could contribute to enhance transmission efficiency at the NMJ.

AB - The Neuromuscular Junction (NMJ) is the place where one end plate terminal of a motor neuron forms a synapse with a muscle fiber. Unlike synapses between neurons, the NMJ is characterized by a large number of voltage-dependent sodium channels located within post-junctional folds of the muscle fiber membrane. In this work we have used a mathematical model to simulate the behavior of the voltage-dependent sodium conductance within the NMJ. Simulations were restricted to sodium channels activation while inactivation was not considered. We observed a self-gating behavior of the sodium conductance, characterized by bistability and hysteresis. According to these results, self-gating of sodium channels in post-junctional folds could contribute to enhance transmission efficiency at the NMJ.

KW - Activation of sodium channels

KW - Self-gating

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DO - 10.1109/NER.2011.5910524

M3 - Conference contribution

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T3 - 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011

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EP - 211

BT - 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011

T2 - 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011

Y2 - 27 April 2011 through 1 May 2011

ER -

Self-gating of sodium channels at neuromuscular junction

Abstract

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Conference

Keywords

ASJC Scopus subject areas

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