Sample preparation of complex biological samples in the analysis of trace-level contaminants

C. Basheer; K. Alhooshani; A. A. Nuhu; S. Kanimozhi; H. K. Lee

doi:10.1016/B978-0-12-381373-2.00109-5

Sample preparation of complex biological samples in the analysis of trace-level contaminants

C. Basheer^*
, K. Alhooshani
, A. A. Nuhu
, S. Kanimozhi
, H. K. Lee

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

8 Scopus citations

Abstract

Determination of trace-level contaminants in complex biological samples has been of increasing demand. Conventional means of this determination for matrices such as urine, blood, and milk may involve multistep sample preparations with a high probability of loss of analytes, and are mostly time-consuming. As a result, simple minimized microextraction procedures such as solid-phase microextraction, stir bar sorptive extraction, liquid-phase microextraction, and electromembrane extraction, which are mostly carried out in one or two steps, are preferred. Recently a number of tailored solid-phase extraction and molecularly imprinted polymer extraction procedures for nonviscous biological liquid samples have been reported. However, for animal tissues and other solid, semisolid, and highly viscous samples, extraction methods may encounter greater difficulties than those for conventional liquid samples. Consequently the preferred sample preparations are simple, step-minimized methods such as pressurized liquid extraction, supercritical fluid extraction and the like. The main advantages of these modern techniques are that they can be customized for simultaneous extraction and cleanup. To date, these techniques have been successfully applied as sample preparation and preconcentration steps in the determination of various analytes of toxicological importance in different biological matrices.

Original language	English
Title of host publication	Comprehensive Sampling and Sample Preparation
Publisher	Elsevier Inc.
Pages	681-700
Number of pages	20
Volume	3
ISBN (Print)	9780123813749
DOIs	https://doi.org/10.1016/B978-0-12-381373-2.00109-5
State	Published - 2012

Bibliographical note

Funding Information:
Solid-Phase Microextraction ; Fundamentals of Supercritical Fluid Extraction ; Sorbent-Phase Sample Preparation in Environmental Analysis ; Recent Advances in Sample Preparation for Pesticide Analysis ; Membrane-Based Extraction for Environmental Analysis ; Sample Pretreatment Techniques for Perfluorinated Compounds ; Accelerated Methods for Sample Preparation in Food ; Solvent-Based Extraction Techniques for the Determination of Pesticides in Food ; Sorbent-Based Techniques for the Determination of Pesticides in Food ; Application of Stir-Bar Sorptive Extraction in Food Analysis ; Membrane-Based Extraction Techniques in Food Analysis Chanbasher Basheer is an Assistant Professor at the Department of Chemistry, King Fahd University of Petroleum and Minerals (KFUPM), Saudi Arabia. He holds a BSc degree from Madras University (India) and a PhD from the National University of Singapore (NUS) and was a faculty member at NUS before joining KFUPM. His research interests are analytical chemistry, environmental analytical chemistry, and novel materials. He has published over 40 papers in scientific journals and his research area is motivated by an interest in microanalytical technology. Khalid Alhooshani has a BSc in chemistry from King Saud University (1994) and an MSc in chemistry from Florida Institute of Technology (2001). He received his PhD in analytical chemistry from University of South Florida in 2005. He is currently an assistant professor of analytical chemistry at King Fahd University of Petroleum and Minerals, Saudi Arabia. His research interests are focused on the fundamentals of separation chemistry, advanced technology for high-performance microseparation columns, and solventless microextraction devices. Abdulmumin A. Nuhu obtained a first-class honors degree, graduating as the best student, in biochemistry from the College of Medical Sciences, University of Maiduguri, Nigeria, in 1995. He served for one year at the Department of Chemistry/Biochemistry, University of Uyo, Nigeria (1995–1996). As Graduate Assistant/Assistant Lecturer, he taught molecular biology and enzymology at the Abubakar Tafawa Balewa University, Bauchi, Nigeria (1997–2004). He is presently pursuing his PhD at the Department of Chemistry, King Fahd University of Petroleum and Minerals, Saudi Arabia. Sivarajan Kanimozhi is pursuing a PhD degree at the Department of Chemistry, National University of Singapore (NUS). She holds an MSc degree from NUS. Her research interest is in bioanalytical chemistry and separation science. Hian Kee Lee is Professor in the Department of Chemistry, National University of Singapore (NUS). He obtained his BSc (Honors) and PhD degrees from the University of Canterbury, New Zealand. His research interests are focused on the development of microscale sample preparation techniques, and microscale separation science and environmental bioanalytics. Specifically, his work is centered on developing and applying liquid-phase microextraction procedures. Professor Lee was an Editor of Analytica Chimica Acta from 2006 to 2011, and was a member of the editorial board of the Journal of Chromatography A from 2005 to 2010. He has also served as an editorial advisor for Analytica Chimica Acta (2003–2005), and as an international advisory board member of the Analyst (1997–2008). He is currently an Editor of the Journal of Chromatography A . He is a current scientific advisory board member of Analytical Sciences , an editorial advisory board member of LC·GC Europe and LC·GC Asia Pacific , and a member of the scientific advisory board of Separation Science , a web-based journal that runs the annual Separation Science Asia Symposium in Singapore. He is a contributor (on liquid-phase microextraction) to the web-based separation science resource, Chromedia . Professor Lee is the co-chairman of the engineering, physical, and chemical sciences cluster of NUS’ University Research Committee, a member of the university’s Cross-Faculty Research Committee that fosters multidisciplinary research across different faculties, and was also a member of the University Promotion and Tenure Committee from 2007 to 2009. He has served as deputy head and head of his department. He is a member of the international audit panel of Singapore’s Water Reclamation and Desalination program. He was a recipient of the NUS Outstanding Research Award (2006), the university’s Faculty of Science Outstanding Scientist Award (2009), and the Federation of Asian Chemical Societies Foundation Lectureship Award (2009). He is a co-editor of the present Comprehensive Sampling and Sample Preparation monograph.

Funding Information:
CB would like to thank the Deanship of Scientific Research at King Fahd University of Petroleum and Minerals for their support (FT100034)

Keywords

Complex biological solid samples
Electromembrane extraction
Liquid-phase microextraction
Matrix solid-phase dispersion
Molecularly imprinted polymers
Pressurized liquid extraction
Solid-phase microextraction
Stir bar sorptive extraction
Supercritical fluid extraction

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1016/B978-0-12-381373-2.00109-5

Cite this

@inbook{9e9c3b98a15a4db1a99673cf0cb12f82,

title = "Sample preparation of complex biological samples in the analysis of trace-level contaminants",

abstract = "Determination of trace-level contaminants in complex biological samples has been of increasing demand. Conventional means of this determination for matrices such as urine, blood, and milk may involve multistep sample preparations with a high probability of loss of analytes, and are mostly time-consuming. As a result, simple minimized microextraction procedures such as solid-phase microextraction, stir bar sorptive extraction, liquid-phase microextraction, and electromembrane extraction, which are mostly carried out in one or two steps, are preferred. Recently a number of tailored solid-phase extraction and molecularly imprinted polymer extraction procedures for nonviscous biological liquid samples have been reported. However, for animal tissues and other solid, semisolid, and highly viscous samples, extraction methods may encounter greater difficulties than those for conventional liquid samples. Consequently the preferred sample preparations are simple, step-minimized methods such as pressurized liquid extraction, supercritical fluid extraction and the like. The main advantages of these modern techniques are that they can be customized for simultaneous extraction and cleanup. To date, these techniques have been successfully applied as sample preparation and preconcentration steps in the determination of various analytes of toxicological importance in different biological matrices.",

keywords = "Complex biological solid samples, Electromembrane extraction, Liquid-phase microextraction, Matrix solid-phase dispersion, Molecularly imprinted polymers, Pressurized liquid extraction, Solid-phase microextraction, Stir bar sorptive extraction, Supercritical fluid extraction",

author = "C. Basheer and K. Alhooshani and Nuhu, \{A. A.\} and S. Kanimozhi and Lee, \{H. K.\}",

note = "Funding Information: Solid-Phase Microextraction ; Fundamentals of Supercritical Fluid Extraction ; Sorbent-Phase Sample Preparation in Environmental Analysis ; Recent Advances in Sample Preparation for Pesticide Analysis ; Membrane-Based Extraction for Environmental Analysis ; Sample Pretreatment Techniques for Perfluorinated Compounds ; Accelerated Methods for Sample Preparation in Food ; Solvent-Based Extraction Techniques for the Determination of Pesticides in Food ; Sorbent-Based Techniques for the Determination of Pesticides in Food ; Application of Stir-Bar Sorptive Extraction in Food Analysis ; Membrane-Based Extraction Techniques in Food Analysis Chanbasher Basheer is an Assistant Professor at the Department of Chemistry, King Fahd University of Petroleum and Minerals (KFUPM), Saudi Arabia. He holds a BSc degree from Madras University (India) and a PhD from the National University of Singapore (NUS) and was a faculty member at NUS before joining KFUPM. His research interests are analytical chemistry, environmental analytical chemistry, and novel materials. He has published over 40 papers in scientific journals and his research area is motivated by an interest in microanalytical technology. Khalid Alhooshani has a BSc in chemistry from King Saud University (1994) and an MSc in chemistry from Florida Institute of Technology (2001). He received his PhD in analytical chemistry from University of South Florida in 2005. He is currently an assistant professor of analytical chemistry at King Fahd University of Petroleum and Minerals, Saudi Arabia. His research interests are focused on the fundamentals of separation chemistry, advanced technology for high-performance microseparation columns, and solventless microextraction devices. Abdulmumin A. Nuhu obtained a first-class honors degree, graduating as the best student, in biochemistry from the College of Medical Sciences, University of Maiduguri, Nigeria, in 1995. He served for one year at the Department of Chemistry/Biochemistry, University of Uyo, Nigeria (1995–1996). As Graduate Assistant/Assistant Lecturer, he taught molecular biology and enzymology at the Abubakar Tafawa Balewa University, Bauchi, Nigeria (1997–2004). He is presently pursuing his PhD at the Department of Chemistry, King Fahd University of Petroleum and Minerals, Saudi Arabia. Sivarajan Kanimozhi is pursuing a PhD degree at the Department of Chemistry, National University of Singapore (NUS). She holds an MSc degree from NUS. Her research interest is in bioanalytical chemistry and separation science. Hian Kee Lee is Professor in the Department of Chemistry, National University of Singapore (NUS). He obtained his BSc (Honors) and PhD degrees from the University of Canterbury, New Zealand. His research interests are focused on the development of microscale sample preparation techniques, and microscale separation science and environmental bioanalytics. Specifically, his work is centered on developing and applying liquid-phase microextraction procedures. Professor Lee was an Editor of Analytica Chimica Acta from 2006 to 2011, and was a member of the editorial board of the Journal of Chromatography A from 2005 to 2010. He has also served as an editorial advisor for Analytica Chimica Acta (2003–2005), and as an international advisory board member of the Analyst (1997–2008). He is currently an Editor of the Journal of Chromatography A . He is a current scientific advisory board member of Analytical Sciences , an editorial advisory board member of LC·GC Europe and LC·GC Asia Pacific , and a member of the scientific advisory board of Separation Science , a web-based journal that runs the annual Separation Science Asia Symposium in Singapore. He is a contributor (on liquid-phase microextraction) to the web-based separation science resource, Chromedia . Professor Lee is the co-chairman of the engineering, physical, and chemical sciences cluster of NUS{\textquoteright} University Research Committee, a member of the university{\textquoteright}s Cross-Faculty Research Committee that fosters multidisciplinary research across different faculties, and was also a member of the University Promotion and Tenure Committee from 2007 to 2009. He has served as deputy head and head of his department. He is a member of the international audit panel of Singapore{\textquoteright}s Water Reclamation and Desalination program. He was a recipient of the NUS Outstanding Research Award (2006), the university{\textquoteright}s Faculty of Science Outstanding Scientist Award (2009), and the Federation of Asian Chemical Societies Foundation Lectureship Award (2009). He is a co-editor of the present Comprehensive Sampling and Sample Preparation monograph. Funding Information: CB would like to thank the Deanship of Scientific Research at King Fahd University of Petroleum and Minerals for their support (FT100034) ",

year = "2012",

doi = "10.1016/B978-0-12-381373-2.00109-5",

language = "English",

isbn = "9780123813749",

volume = "3",

pages = "681--700",

booktitle = "Comprehensive Sampling and Sample Preparation",

publisher = "Elsevier Inc.",

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}

TY - CHAP

T1 - Sample preparation of complex biological samples in the analysis of trace-level contaminants

AU - Basheer, C.

AU - Alhooshani, K.

AU - Nuhu, A. A.

AU - Kanimozhi, S.

AU - Lee, H. K.

N1 - Funding Information: Solid-Phase Microextraction ; Fundamentals of Supercritical Fluid Extraction ; Sorbent-Phase Sample Preparation in Environmental Analysis ; Recent Advances in Sample Preparation for Pesticide Analysis ; Membrane-Based Extraction for Environmental Analysis ; Sample Pretreatment Techniques for Perfluorinated Compounds ; Accelerated Methods for Sample Preparation in Food ; Solvent-Based Extraction Techniques for the Determination of Pesticides in Food ; Sorbent-Based Techniques for the Determination of Pesticides in Food ; Application of Stir-Bar Sorptive Extraction in Food Analysis ; Membrane-Based Extraction Techniques in Food Analysis Chanbasher Basheer is an Assistant Professor at the Department of Chemistry, King Fahd University of Petroleum and Minerals (KFUPM), Saudi Arabia. He holds a BSc degree from Madras University (India) and a PhD from the National University of Singapore (NUS) and was a faculty member at NUS before joining KFUPM. His research interests are analytical chemistry, environmental analytical chemistry, and novel materials. He has published over 40 papers in scientific journals and his research area is motivated by an interest in microanalytical technology. Khalid Alhooshani has a BSc in chemistry from King Saud University (1994) and an MSc in chemistry from Florida Institute of Technology (2001). He received his PhD in analytical chemistry from University of South Florida in 2005. He is currently an assistant professor of analytical chemistry at King Fahd University of Petroleum and Minerals, Saudi Arabia. His research interests are focused on the fundamentals of separation chemistry, advanced technology for high-performance microseparation columns, and solventless microextraction devices. Abdulmumin A. Nuhu obtained a first-class honors degree, graduating as the best student, in biochemistry from the College of Medical Sciences, University of Maiduguri, Nigeria, in 1995. He served for one year at the Department of Chemistry/Biochemistry, University of Uyo, Nigeria (1995–1996). As Graduate Assistant/Assistant Lecturer, he taught molecular biology and enzymology at the Abubakar Tafawa Balewa University, Bauchi, Nigeria (1997–2004). He is presently pursuing his PhD at the Department of Chemistry, King Fahd University of Petroleum and Minerals, Saudi Arabia. Sivarajan Kanimozhi is pursuing a PhD degree at the Department of Chemistry, National University of Singapore (NUS). She holds an MSc degree from NUS. Her research interest is in bioanalytical chemistry and separation science. Hian Kee Lee is Professor in the Department of Chemistry, National University of Singapore (NUS). He obtained his BSc (Honors) and PhD degrees from the University of Canterbury, New Zealand. His research interests are focused on the development of microscale sample preparation techniques, and microscale separation science and environmental bioanalytics. Specifically, his work is centered on developing and applying liquid-phase microextraction procedures. Professor Lee was an Editor of Analytica Chimica Acta from 2006 to 2011, and was a member of the editorial board of the Journal of Chromatography A from 2005 to 2010. He has also served as an editorial advisor for Analytica Chimica Acta (2003–2005), and as an international advisory board member of the Analyst (1997–2008). He is currently an Editor of the Journal of Chromatography A . He is a current scientific advisory board member of Analytical Sciences , an editorial advisory board member of LC·GC Europe and LC·GC Asia Pacific , and a member of the scientific advisory board of Separation Science , a web-based journal that runs the annual Separation Science Asia Symposium in Singapore. He is a contributor (on liquid-phase microextraction) to the web-based separation science resource, Chromedia . Professor Lee is the co-chairman of the engineering, physical, and chemical sciences cluster of NUS’ University Research Committee, a member of the university’s Cross-Faculty Research Committee that fosters multidisciplinary research across different faculties, and was also a member of the University Promotion and Tenure Committee from 2007 to 2009. He has served as deputy head and head of his department. He is a member of the international audit panel of Singapore’s Water Reclamation and Desalination program. He was a recipient of the NUS Outstanding Research Award (2006), the university’s Faculty of Science Outstanding Scientist Award (2009), and the Federation of Asian Chemical Societies Foundation Lectureship Award (2009). He is a co-editor of the present Comprehensive Sampling and Sample Preparation monograph. Funding Information: CB would like to thank the Deanship of Scientific Research at King Fahd University of Petroleum and Minerals for their support (FT100034)

PY - 2012

Y1 - 2012

N2 - Determination of trace-level contaminants in complex biological samples has been of increasing demand. Conventional means of this determination for matrices such as urine, blood, and milk may involve multistep sample preparations with a high probability of loss of analytes, and are mostly time-consuming. As a result, simple minimized microextraction procedures such as solid-phase microextraction, stir bar sorptive extraction, liquid-phase microextraction, and electromembrane extraction, which are mostly carried out in one or two steps, are preferred. Recently a number of tailored solid-phase extraction and molecularly imprinted polymer extraction procedures for nonviscous biological liquid samples have been reported. However, for animal tissues and other solid, semisolid, and highly viscous samples, extraction methods may encounter greater difficulties than those for conventional liquid samples. Consequently the preferred sample preparations are simple, step-minimized methods such as pressurized liquid extraction, supercritical fluid extraction and the like. The main advantages of these modern techniques are that they can be customized for simultaneous extraction and cleanup. To date, these techniques have been successfully applied as sample preparation and preconcentration steps in the determination of various analytes of toxicological importance in different biological matrices.

AB - Determination of trace-level contaminants in complex biological samples has been of increasing demand. Conventional means of this determination for matrices such as urine, blood, and milk may involve multistep sample preparations with a high probability of loss of analytes, and are mostly time-consuming. As a result, simple minimized microextraction procedures such as solid-phase microextraction, stir bar sorptive extraction, liquid-phase microextraction, and electromembrane extraction, which are mostly carried out in one or two steps, are preferred. Recently a number of tailored solid-phase extraction and molecularly imprinted polymer extraction procedures for nonviscous biological liquid samples have been reported. However, for animal tissues and other solid, semisolid, and highly viscous samples, extraction methods may encounter greater difficulties than those for conventional liquid samples. Consequently the preferred sample preparations are simple, step-minimized methods such as pressurized liquid extraction, supercritical fluid extraction and the like. The main advantages of these modern techniques are that they can be customized for simultaneous extraction and cleanup. To date, these techniques have been successfully applied as sample preparation and preconcentration steps in the determination of various analytes of toxicological importance in different biological matrices.

KW - Complex biological solid samples

KW - Electromembrane extraction

KW - Liquid-phase microextraction

KW - Matrix solid-phase dispersion

KW - Molecularly imprinted polymers

KW - Pressurized liquid extraction

KW - Solid-phase microextraction

KW - Stir bar sorptive extraction

KW - Supercritical fluid extraction

UR - https://www.scopus.com/pages/publications/84883952485

U2 - 10.1016/B978-0-12-381373-2.00109-5

DO - 10.1016/B978-0-12-381373-2.00109-5

M3 - Chapter

AN - SCOPUS:84883952485

SN - 9780123813749

VL - 3

SP - 681

EP - 700

BT - Comprehensive Sampling and Sample Preparation

PB - Elsevier Inc.

ER -

Sample preparation of complex biological samples in the analysis of trace-level contaminants

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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