TY - JOUR
T1 - Ru(II)-based antineoplastic
T2 - A “wingtip” N-heterocyclic carbene facilitates access to a new class of organometallics that are cytotoxic to common cancer cell lines
AU - Mondal, Ambarish
AU - Tripathy, Rajat K.
AU - Dutta, Parul
AU - Santra, Manas Kumar
AU - Isab, Anvarhusein A.
AU - Bielawski, Christopher W.
AU - Kisan, Hemanta K.
AU - Chandra, Swapan K.
AU - Dinda, Joydev
N1 - Publisher Copyright:
© 2018 John Wiley & Sons, Ltd.
PY - 2019/1
Y1 - 2019/1
N2 - The syntheses, structures, and chemotherapeutic activities of Ag(I)-, Au(I)-, and Ru(II)-complexes ligated to a novel N-heterocyclic carbene ligand, 2-(4-nitrophenyl)imidazo[1,5-a]pyridin-2-ylidene (1), are described. The corresponding complexes, [Ag(1)2][PF6], [Au(1)2][PF6] (3), and [Ru(1)(p-cymene)Cl][PF6] (4), were prepared using convenient transmetallation chemistry and characterized using a range of spectroscopic and analytical techniques. X-ray crystallography revealed that complexes 2 and 3 adopted linear structures whereas 4 exhibited a prototypical “piano-stool”-like geometry; the structural assignments were further supported by DFT calculations. A series of in vitro studies revealed that while the aforementioned Ag(I), Au(I) and Ru(II) complexes exhibited significant cytotoxicities against the human colon adenocarcinoma (HCT 116), lung cancer (A549), and breast cancer (MCF7) cell lines, the Ru derivative was most prominent.
AB - The syntheses, structures, and chemotherapeutic activities of Ag(I)-, Au(I)-, and Ru(II)-complexes ligated to a novel N-heterocyclic carbene ligand, 2-(4-nitrophenyl)imidazo[1,5-a]pyridin-2-ylidene (1), are described. The corresponding complexes, [Ag(1)2][PF6], [Au(1)2][PF6] (3), and [Ru(1)(p-cymene)Cl][PF6] (4), were prepared using convenient transmetallation chemistry and characterized using a range of spectroscopic and analytical techniques. X-ray crystallography revealed that complexes 2 and 3 adopted linear structures whereas 4 exhibited a prototypical “piano-stool”-like geometry; the structural assignments were further supported by DFT calculations. A series of in vitro studies revealed that while the aforementioned Ag(I), Au(I) and Ru(II) complexes exhibited significant cytotoxicities against the human colon adenocarcinoma (HCT 116), lung cancer (A549), and breast cancer (MCF7) cell lines, the Ru derivative was most prominent.
KW - Gold(I)-NHC
KW - N-heterocyclic carbene
KW - cytotoxicity
KW - silver(I)-NHC
UR - https://www.scopus.com/pages/publications/85058036405
U2 - 10.1002/aoc.4692
DO - 10.1002/aoc.4692
M3 - Article
AN - SCOPUS:85058036405
SN - 0268-2605
VL - 33
JO - Applied Organometallic Chemistry
JF - Applied Organometallic Chemistry
IS - 1
M1 - e4692
ER -
