Relayed hyperpolarization from: Para -hydrogen improves the NMR detectability of alcohols

Peter J. Rayner; Ben J. Tickner; Wissam Iali; Marianna Fekete; Alastair D. Robinson; Simon B. Duckett

doi:10.1039/c9sc02765c

Relayed hyperpolarization from: Para -hydrogen improves the NMR detectability of alcohols

Peter J. Rayner
, Ben J. Tickner
, Wissam Iali
, Marianna Fekete
, Alastair D. Robinson
, Simon B. Duckett^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The detection of alcohols by magnetic resonance techniques is important for their characterization and the monitoring of chemical change. Hyperpolarization processes can make previously inpractical measurements, such as the determination of low concentration intermediates, possible. Here, we investigate the SABRE-Relay method in order to define its key characteristics and improve the resulting ¹H NMR signal gains which subsequently approach 10³ per proton. We identify optimal amine proton transfer agents for SABRE-Relay and show how catalyst structure influences the outcome. The breadth of the method is revealed by expansion to more complex alcohols and the polarization of heteronuclei.

Original language	English
Pages (from-to)	7709-7717
Number of pages	9
Journal	Chemical Science
Volume	10
Issue number	33
DOIs	https://doi.org/10.1039/c9sc02765c
State	Published - 2019
Externally published	Yes

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Publisher Copyright:
This journal is © The Royal Society of Chemistry.

ASJC Scopus subject areas

General Chemistry

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10.1039/c9sc02765c

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title = "Relayed hyperpolarization from: Para -hydrogen improves the NMR detectability of alcohols",

abstract = "The detection of alcohols by magnetic resonance techniques is important for their characterization and the monitoring of chemical change. Hyperpolarization processes can make previously inpractical measurements, such as the determination of low concentration intermediates, possible. Here, we investigate the SABRE-Relay method in order to define its key characteristics and improve the resulting 1H NMR signal gains which subsequently approach 103 per proton. We identify optimal amine proton transfer agents for SABRE-Relay and show how catalyst structure influences the outcome. The breadth of the method is revealed by expansion to more complex alcohols and the polarization of heteronuclei.",

author = "Rayner, \{Peter J.\} and Tickner, \{Ben J.\} and Wissam Iali and Marianna Fekete and Robinson, \{Alastair D.\} and Duckett, \{Simon B.\}",

note = "Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9sc02765c",

language = "English",

volume = "10",

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T2 - Para -hydrogen improves the NMR detectability of alcohols

AU - Rayner, Peter J.

AU - Tickner, Ben J.

AU - Iali, Wissam

AU - Fekete, Marianna

AU - Robinson, Alastair D.

AU - Duckett, Simon B.

PY - 2019

Y1 - 2019

N2 - The detection of alcohols by magnetic resonance techniques is important for their characterization and the monitoring of chemical change. Hyperpolarization processes can make previously inpractical measurements, such as the determination of low concentration intermediates, possible. Here, we investigate the SABRE-Relay method in order to define its key characteristics and improve the resulting 1H NMR signal gains which subsequently approach 103 per proton. We identify optimal amine proton transfer agents for SABRE-Relay and show how catalyst structure influences the outcome. The breadth of the method is revealed by expansion to more complex alcohols and the polarization of heteronuclei.

AB - The detection of alcohols by magnetic resonance techniques is important for their characterization and the monitoring of chemical change. Hyperpolarization processes can make previously inpractical measurements, such as the determination of low concentration intermediates, possible. Here, we investigate the SABRE-Relay method in order to define its key characteristics and improve the resulting 1H NMR signal gains which subsequently approach 103 per proton. We identify optimal amine proton transfer agents for SABRE-Relay and show how catalyst structure influences the outcome. The breadth of the method is revealed by expansion to more complex alcohols and the polarization of heteronuclei.

UR - https://www.scopus.com/pages/publications/85071274763

U2 - 10.1039/c9sc02765c

DO - 10.1039/c9sc02765c

M3 - Article

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VL - 10

SP - 7709

EP - 7717

JO - Chemical Science

JF - Chemical Science

IS - 33

ER -

Relayed hyperpolarization from: Para -hydrogen improves the NMR detectability of alcohols

Abstract

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