Quinazolin-4(3H)-ones: A tangible synthesis protocol via an oxidative olefin bond cleavage using metal-catalyst free conditions

Muhammad Sharif

doi:10.3390/APP10082815

Quinazolin-4(3H)-ones: A tangible synthesis protocol via an oxidative olefin bond cleavage using metal-catalyst free conditions

Muhammad Sharif^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

An ecient and selective oxidative procedure for the synthesis of quinazolinones from readily available o-aminobenzamides and styrenes was developed. A number of potentially pharmacologically relevant quinazolinones were prepared using metal-and catalyst-free conditions. The synthesis procedure highlights the sustainable operation, low-priced, free from perilous materials, green solvent and environmental affability. The synthesized products were isolated in moderate to excellent yields.

Original language	English
Article number	2815
Journal	Applied Sciences (Switzerland)
Volume	10
Issue number	8
DOIs	https://doi.org/10.3390/APP10082815
State	Published - 1 Apr 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 by the authors.

Keywords

Anticancer
Antioxidant
Catalysis
Catalyst-free
Metal-free
O-aminobenzamide
Quinazolinone
Styrene

ASJC Scopus subject areas

General Materials Science
Instrumentation
General Engineering
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/APP10082815

Cite this

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title = "Quinazolin-4(3H)-ones: A tangible synthesis protocol via an oxidative olefin bond cleavage using metal-catalyst free conditions",

abstract = "An ecient and selective oxidative procedure for the synthesis of quinazolinones from readily available o-aminobenzamides and styrenes was developed. A number of potentially pharmacologically relevant quinazolinones were prepared using metal-and catalyst-free conditions. The synthesis procedure highlights the sustainable operation, low-priced, free from perilous materials, green solvent and environmental affability. The synthesized products were isolated in moderate to excellent yields.",

keywords = "Anticancer, Antioxidant, Catalysis, Catalyst-free, Metal-free, O-aminobenzamide, Quinazolinone, Styrene",

author = "Muhammad Sharif",

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doi = "10.3390/APP10082815",

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N2 - An ecient and selective oxidative procedure for the synthesis of quinazolinones from readily available o-aminobenzamides and styrenes was developed. A number of potentially pharmacologically relevant quinazolinones were prepared using metal-and catalyst-free conditions. The synthesis procedure highlights the sustainable operation, low-priced, free from perilous materials, green solvent and environmental affability. The synthesized products were isolated in moderate to excellent yields.

AB - An ecient and selective oxidative procedure for the synthesis of quinazolinones from readily available o-aminobenzamides and styrenes was developed. A number of potentially pharmacologically relevant quinazolinones were prepared using metal-and catalyst-free conditions. The synthesis procedure highlights the sustainable operation, low-priced, free from perilous materials, green solvent and environmental affability. The synthesized products were isolated in moderate to excellent yields.

KW - Anticancer

KW - Antioxidant

KW - Catalysis

KW - Catalyst-free

KW - Metal-free

KW - O-aminobenzamide

KW - Quinazolinone

KW - Styrene

UR - https://www.scopus.com/pages/publications/85084638568

U2 - 10.3390/APP10082815

DO - 10.3390/APP10082815

M3 - Article

AN - SCOPUS:85084638568

SN - 2076-3417

VL - 10

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 8

M1 - 2815

ER -

Quinazolin-4(3H)-ones: A tangible synthesis protocol via an oxidative olefin bond cleavage using metal-catalyst free conditions

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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Cite this