Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: What next?

Carol Hopkins Sibley; John E. Hyde; Paul F.G. Sims; Christopher V. Plowe; James G. Kublin; Edward K. Mberu; Alan F. Cowman; Peter A. Winstanley; William M. Watkins; Alexis M. Nzila

doi:10.1016/S1471-4922(01)02085-2

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: What next?

Carol Hopkins Sibley^*, John E. Hyde, Paul F.G. Sims, Christopher V. Plowe, James G. Kublin, Edward K. Mberu, Alan F. Cowman, Peter A. Winstanley, William M. Watkins, Alexis M. Nzila

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

327 Scopus citations

Abstract

Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative. Resistant populations of Plasmodium falciparum were selected extremely rapidly in Southeast Asia and South America. If this happens in sub-Saharan Africa, it will be a public health disaster because no inexpensive alternative is currently available. This article reviews the molecular mechanisms of this resistance and discusses how to extend the therapeutic life of antifolate drugs.

Original language	English
Pages (from-to)	582-588
Number of pages	7
Journal	Trends in Parasitology
Volume	17
Issue number	12
DOIs	https://doi.org/10.1016/S1471-4922(01)02085-2
State	Published - 1 Dec 2001
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1471-4922(01)02085-2

Cite this

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title = "Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: What next?",

abstract = "Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative. Resistant populations of Plasmodium falciparum were selected extremely rapidly in Southeast Asia and South America. If this happens in sub-Saharan Africa, it will be a public health disaster because no inexpensive alternative is currently available. This article reviews the molecular mechanisms of this resistance and discusses how to extend the therapeutic life of antifolate drugs.",

author = "Sibley, {Carol Hopkins} and Hyde, {John E.} and Sims, {Paul F.G.} and Plowe, {Christopher V.} and Kublin, {James G.} and Mberu, {Edward K.} and Cowman, {Alan F.} and Winstanley, {Peter A.} and Watkins, {William M.} and Nzila, {Alexis M.}",

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language = "English",

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TY - JOUR

T1 - Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum

T2 - What next?

AU - Sibley, Carol Hopkins

AU - Hyde, John E.

AU - Sims, Paul F.G.

AU - Plowe, Christopher V.

AU - Kublin, James G.

AU - Mberu, Edward K.

AU - Cowman, Alan F.

AU - Winstanley, Peter A.

AU - Watkins, William M.

AU - Nzila, Alexis M.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative. Resistant populations of Plasmodium falciparum were selected extremely rapidly in Southeast Asia and South America. If this happens in sub-Saharan Africa, it will be a public health disaster because no inexpensive alternative is currently available. This article reviews the molecular mechanisms of this resistance and discusses how to extend the therapeutic life of antifolate drugs.

AB - Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative. Resistant populations of Plasmodium falciparum were selected extremely rapidly in Southeast Asia and South America. If this happens in sub-Saharan Africa, it will be a public health disaster because no inexpensive alternative is currently available. This article reviews the molecular mechanisms of this resistance and discusses how to extend the therapeutic life of antifolate drugs.

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U2 - 10.1016/S1471-4922(01)02085-2

DO - 10.1016/S1471-4922(01)02085-2

M3 - Review article

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AN - SCOPUS:0035702490

SN - 1471-4922

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JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 12

ER -

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: What next?

Abstract

ASJC Scopus subject areas

UN SDGs

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