Preparation, spectral characterization and antibacterial studies of silver(I) complexes of 2-mercaptopyridine and thiomalate

Muhammad Hanif; Aisha Saddiqa; Shahida Hasnain; Saeed Ahmad; Ghulam Rabbani; Anvarhusein A. Isab

doi:10.3233/SPE-2008-0328

Preparation, spectral characterization and antibacterial studies of silver(I) complexes of 2-mercaptopyridine and thiomalate

Muhammad Hanif
, Aisha Saddiqa
, Shahida Hasnain
, Saeed Ahmad^*
, Ghulam Rabbani
, Anvarhusein A. Isab

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Silver(I) complexes of 2-mercaptopyridine (Mpy), [Ag(Mpy)]NO₃ and [Ag(Mpy)₂]NO₃, and the first mixed-ligand complex having a thione and thiolate coordinated to Ag(I), [Mpy-Ag-Tm] (Tm=thiomalate) have been prepared and characterized by IR and NMR spectroscopy. The ¹H and ¹³C NMR spectra show the presence of both ligands in the mixed-ligand complex, [Mpy-Ag-Tm]. An upfield shift is observed in the >C=S resonance of Mpy and C=O resonances of thiomalate in ¹³C NMR, while the other resonances are shifted downfield. The complexes showed relatively high antibacterial activity (inhibition zone of 6-11 mm) against a gram +ve bacterium, Bacillus subtilis, as compared to that (inhibition zone of 4 mm) against a gram -ve bacterium, Escherichia coli.

Original language	English
Pages (from-to)	51-56
Number of pages	6
Journal	Spectroscopy
Volume	22
Issue number	1
DOIs	https://doi.org/10.3233/SPE-2008-0328
State	Published - 2008

Keywords

2-mercaptopyridine
Antibacterial activity
Silver(I) complexes
Thiomalate

ASJC Scopus subject areas

Spectroscopy

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10.3233/SPE-2008-0328

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@article{eaa557dfb2914986917565508c6b0f71,

title = "Preparation, spectral characterization and antibacterial studies of silver(I) complexes of 2-mercaptopyridine and thiomalate",

abstract = "Silver(I) complexes of 2-mercaptopyridine (Mpy), [Ag(Mpy)]NO3 and [Ag(Mpy)2]NO3, and the first mixed-ligand complex having a thione and thiolate coordinated to Ag(I), [Mpy-Ag-Tm] (Tm=thiomalate) have been prepared and characterized by IR and NMR spectroscopy. The 1H and 13C NMR spectra show the presence of both ligands in the mixed-ligand complex, [Mpy-Ag-Tm]. An upfield shift is observed in the >C=S resonance of Mpy and C=O resonances of thiomalate in 13C NMR, while the other resonances are shifted downfield. The complexes showed relatively high antibacterial activity (inhibition zone of 6-11 mm) against a gram +ve bacterium, Bacillus subtilis, as compared to that (inhibition zone of 4 mm) against a gram -ve bacterium, Escherichia coli.",

keywords = "2-mercaptopyridine, Antibacterial activity, Silver(I) complexes, Thiomalate",

author = "Muhammad Hanif and Aisha Saddiqa and Shahida Hasnain and Saeed Ahmad and Ghulam Rabbani and Isab, \{Anvarhusein A.\}",

year = "2008",

doi = "10.3233/SPE-2008-0328",

language = "English",

volume = "22",

pages = "51--56",

journal = "Spectroscopy",

issn = "0712-4813",

publisher = "IOS Press BV",

number = "1",

}

TY - JOUR

T1 - Preparation, spectral characterization and antibacterial studies of silver(I) complexes of 2-mercaptopyridine and thiomalate

AU - Hanif, Muhammad

AU - Saddiqa, Aisha

AU - Hasnain, Shahida

AU - Ahmad, Saeed

AU - Rabbani, Ghulam

AU - Isab, Anvarhusein A.

PY - 2008

Y1 - 2008

N2 - Silver(I) complexes of 2-mercaptopyridine (Mpy), [Ag(Mpy)]NO3 and [Ag(Mpy)2]NO3, and the first mixed-ligand complex having a thione and thiolate coordinated to Ag(I), [Mpy-Ag-Tm] (Tm=thiomalate) have been prepared and characterized by IR and NMR spectroscopy. The 1H and 13C NMR spectra show the presence of both ligands in the mixed-ligand complex, [Mpy-Ag-Tm]. An upfield shift is observed in the >C=S resonance of Mpy and C=O resonances of thiomalate in 13C NMR, while the other resonances are shifted downfield. The complexes showed relatively high antibacterial activity (inhibition zone of 6-11 mm) against a gram +ve bacterium, Bacillus subtilis, as compared to that (inhibition zone of 4 mm) against a gram -ve bacterium, Escherichia coli.

AB - Silver(I) complexes of 2-mercaptopyridine (Mpy), [Ag(Mpy)]NO3 and [Ag(Mpy)2]NO3, and the first mixed-ligand complex having a thione and thiolate coordinated to Ag(I), [Mpy-Ag-Tm] (Tm=thiomalate) have been prepared and characterized by IR and NMR spectroscopy. The 1H and 13C NMR spectra show the presence of both ligands in the mixed-ligand complex, [Mpy-Ag-Tm]. An upfield shift is observed in the >C=S resonance of Mpy and C=O resonances of thiomalate in 13C NMR, while the other resonances are shifted downfield. The complexes showed relatively high antibacterial activity (inhibition zone of 6-11 mm) against a gram +ve bacterium, Bacillus subtilis, as compared to that (inhibition zone of 4 mm) against a gram -ve bacterium, Escherichia coli.

KW - 2-mercaptopyridine

KW - Antibacterial activity

KW - Silver(I) complexes

KW - Thiomalate

UR - https://www.scopus.com/pages/publications/42149146796

U2 - 10.3233/SPE-2008-0328

DO - 10.3233/SPE-2008-0328

M3 - Article

AN - SCOPUS:42149146796

SN - 0712-4813

VL - 22

SP - 51

EP - 56

JO - Spectroscopy

JF - Spectroscopy

IS - 1

ER -

Preparation, spectral characterization and antibacterial studies of silver(I) complexes of 2-mercaptopyridine and thiomalate

Abstract

Keywords

ASJC Scopus subject areas

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