Preparation and characterization of Pectin/Polypyrrole based multifunctional coatings on TiNbZr alloy for orthopaedic applications

A. Madhan Kumar*, Akeem Yusuf Adesina, M. A. Hussein, Saviour A. Umoren, Suresh Ramakrishna, S. Saravanan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Being a natural and renewable polysaccharide, pectin (PC) is considered a polymer with promising potential for many applications. In the present investigation, novel multifunctional pectin/polypyrrole (PC/PPy) composite coatings loaded with gentamicin (GM) were electrochemically deposited on TiNbZr alloy to enhance its biocompatibility, antibacterial performance and corrosion resistance in physiological environment. Various surface and structural characterization techniques were deployed to examine the composite coatings. in vitro corrosion analysis confirmed that the composite coated TiNbZr specimen exhibited higher corrosion resistant performance in simulated body fluid (SBF). The drug release kinetics was estimated and the results corroborated the sustained release of GM from the controlled degradation of the composite matrix. The pectin composite coatings exhibited effective antibacterial performance; due to the sustained release of GM. In-vitro cell culture studies validated the improved biocompatibility of the composite coatings. Among the developed coatings, composite coatings loaded with 10 wt. % of GM exhibited the lowest corrosion rate, enhanced biocompatibility, and antibacterial performance.

Original languageEnglish
Article number116285
JournalCarbohydrate Polymers
Volume242
DOIs
StatePublished - 15 Aug 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd

Keywords

  • Antibacterial
  • Biocompatibility
  • Coatings
  • Corrosion
  • Pectin
  • Polypyrrole

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Preparation and characterization of Pectin/Polypyrrole based multifunctional coatings on TiNbZr alloy for orthopaedic applications'. Together they form a unique fingerprint.

Cite this