Practical Heck-Mizoroki coupling protocol for challenging substrates mediated by an N-heterocyclic carbene-ligated palladacycle

Eric Assen B. Kantchev; Guang Rong Peh; Chi Zhang; Jackie Y. Ying

doi:10.1021/ol8012809

Practical Heck-Mizoroki coupling protocol for challenging substrates mediated by an N-heterocyclic carbene-ligated palladacycle

Eric Assen B. Kantchev^*, Guang Rong Peh, Chi Zhang, Jackie Y. Ying

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

(Chemical Equation Presented) A highly active, N-heterocyclic carbene-palladacycle precatalyst for the Heck-Mizoroki reaction was rationally designed. The complex can be synthesized on a large scale in excellent yield by a novel, one-pot, three-component reaction and is tolerant to air, moisture, and long-term storage. A wide range of challenging substrates is successfully coupled under a simple and user-friendly reaction protocol.

Original language	English
Pages (from-to)	3949-3952
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	18
DOIs	https://doi.org/10.1021/ol8012809
State	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol8012809

Cite this

@article{06c0629f9c00421c850ac9b58a09c7e0,

title = "Practical Heck-Mizoroki coupling protocol for challenging substrates mediated by an N-heterocyclic carbene-ligated palladacycle",

abstract = "(Chemical Equation Presented) A highly active, N-heterocyclic carbene-palladacycle precatalyst for the Heck-Mizoroki reaction was rationally designed. The complex can be synthesized on a large scale in excellent yield by a novel, one-pot, three-component reaction and is tolerant to air, moisture, and long-term storage. A wide range of challenging substrates is successfully coupled under a simple and user-friendly reaction protocol.",

author = "Kantchev, \{Eric Assen B.\} and Peh, \{Guang Rong\} and Chi Zhang and Ying, \{Jackie Y.\}",

year = "2008",

doi = "10.1021/ol8012809",

language = "English",

volume = "10",

pages = "3949--3952",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "18",

}

TY - JOUR

T1 - Practical Heck-Mizoroki coupling protocol for challenging substrates mediated by an N-heterocyclic carbene-ligated palladacycle

AU - Kantchev, Eric Assen B.

AU - Peh, Guang Rong

AU - Zhang, Chi

AU - Ying, Jackie Y.

PY - 2008

Y1 - 2008

N2 - (Chemical Equation Presented) A highly active, N-heterocyclic carbene-palladacycle precatalyst for the Heck-Mizoroki reaction was rationally designed. The complex can be synthesized on a large scale in excellent yield by a novel, one-pot, three-component reaction and is tolerant to air, moisture, and long-term storage. A wide range of challenging substrates is successfully coupled under a simple and user-friendly reaction protocol.

AB - (Chemical Equation Presented) A highly active, N-heterocyclic carbene-palladacycle precatalyst for the Heck-Mizoroki reaction was rationally designed. The complex can be synthesized on a large scale in excellent yield by a novel, one-pot, three-component reaction and is tolerant to air, moisture, and long-term storage. A wide range of challenging substrates is successfully coupled under a simple and user-friendly reaction protocol.

UR - https://www.scopus.com/pages/publications/55949121369

U2 - 10.1021/ol8012809

DO - 10.1021/ol8012809

M3 - Article

C2 - 18710241

AN - SCOPUS:55949121369

SN - 1523-7060

VL - 10

SP - 3949

EP - 3952

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Practical Heck-Mizoroki coupling protocol for challenging substrates mediated by an N-heterocyclic carbene-ligated palladacycle

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this