Potentiometric assay of antipsychotic drug (Ziprasidone Hydrochloride) in pharmaceuticals, serum and urine

Vinod K. Gupta; Shilpi Agarwal; Barkha Singhal

doi:10.1016/s1452-3981(23)18235-6

Potentiometric assay of antipsychotic drug (Ziprasidone Hydrochloride) in pharmaceuticals, serum and urine

Vinod K. Gupta^*, Shilpi Agarwal, Barkha Singhal

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The membranes of ziprasidone hydrochloride-tetraphenyl borate, (Zp-TPB), chlorophenyl borate (Zp-ClPB), phosphotungstate (Zp₃-PT), ion associations as molecular recognition reagent dispersed in PVC matrix with dibutylphthalate as plasticizer have been proposed for quantification of ziprasidone hydrochloride. The performance characteristics revealed a fast, stable and liner response for ziprasidone over the concentration ranges of 8.5 × 10^-6-1.0 × 10^-2 M, 3.9 × 10^-6-1.0 × 10^-2M, 7.7 × 10^-7-1.0 × 10^-2 M ZpCl with cationic slopes of 57.0, 56.0, 58.5 mV/decade respectively. The solubility product of the ion-pair and the formation constant of the precipitation reaction leading to the ion-pair formation were determined conductometrically. The potentiometric determination of ziprasidone hydrochloride ion in different pharmaceutical preparations and biological fluids has been achieved without any interference from various excipients and diluents commonly used in drug formulations. Validation of the method shows suitability of the proposed electrodes for use in the quality control assessment of ziprasidone hydrochloride. The proposed potentiometric methods offer the advantages of high-throughput determination, simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.

Original language	English
Pages (from-to)	3036-3056
Number of pages	21
Journal	International Journal of Electrochemical Science
Volume	6
Issue number	7
DOIs	https://doi.org/10.1016/s1452-3981(23)18235-6
State	Published - Jul 2011
Externally published	Yes

Keywords

Ion-pair
Membrane selective electrodes
Neutral carriers
Pharmaceutical analysis
Solubility product

ASJC Scopus subject areas

Electrochemistry

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10.1016/s1452-3981(23)18235-6

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title = "Potentiometric assay of antipsychotic drug (Ziprasidone Hydrochloride) in pharmaceuticals, serum and urine",

abstract = "The membranes of ziprasidone hydrochloride-tetraphenyl borate, (Zp-TPB), chlorophenyl borate (Zp-ClPB), phosphotungstate (Zp3-PT), ion associations as molecular recognition reagent dispersed in PVC matrix with dibutylphthalate as plasticizer have been proposed for quantification of ziprasidone hydrochloride. The performance characteristics revealed a fast, stable and liner response for ziprasidone over the concentration ranges of 8.5 × 10-6-1.0 × 10-2 M, 3.9 × 10-6-1.0 × 10-2M, 7.7 × 10-7-1.0 × 10-2 M ZpCl with cationic slopes of 57.0, 56.0, 58.5 mV/decade respectively. The solubility product of the ion-pair and the formation constant of the precipitation reaction leading to the ion-pair formation were determined conductometrically. The potentiometric determination of ziprasidone hydrochloride ion in different pharmaceutical preparations and biological fluids has been achieved without any interference from various excipients and diluents commonly used in drug formulations. Validation of the method shows suitability of the proposed electrodes for use in the quality control assessment of ziprasidone hydrochloride. The proposed potentiometric methods offer the advantages of high-throughput determination, simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.",

keywords = "Ion-pair, Membrane selective electrodes, Neutral carriers, Pharmaceutical analysis, Solubility product",

author = "Gupta, \{Vinod K.\} and Shilpi Agarwal and Barkha Singhal",

year = "2011",

month = jul,

doi = "10.1016/s1452-3981(23)18235-6",

language = "English",

volume = "6",

pages = "3036--3056",

journal = "International Journal of Electrochemical Science",

issn = "1452-3981",

publisher = "Elsevier B.V.",

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}

TY - JOUR

T1 - Potentiometric assay of antipsychotic drug (Ziprasidone Hydrochloride) in pharmaceuticals, serum and urine

AU - Gupta, Vinod K.

AU - Agarwal, Shilpi

AU - Singhal, Barkha

PY - 2011/7

Y1 - 2011/7

N2 - The membranes of ziprasidone hydrochloride-tetraphenyl borate, (Zp-TPB), chlorophenyl borate (Zp-ClPB), phosphotungstate (Zp3-PT), ion associations as molecular recognition reagent dispersed in PVC matrix with dibutylphthalate as plasticizer have been proposed for quantification of ziprasidone hydrochloride. The performance characteristics revealed a fast, stable and liner response for ziprasidone over the concentration ranges of 8.5 × 10-6-1.0 × 10-2 M, 3.9 × 10-6-1.0 × 10-2M, 7.7 × 10-7-1.0 × 10-2 M ZpCl with cationic slopes of 57.0, 56.0, 58.5 mV/decade respectively. The solubility product of the ion-pair and the formation constant of the precipitation reaction leading to the ion-pair formation were determined conductometrically. The potentiometric determination of ziprasidone hydrochloride ion in different pharmaceutical preparations and biological fluids has been achieved without any interference from various excipients and diluents commonly used in drug formulations. Validation of the method shows suitability of the proposed electrodes for use in the quality control assessment of ziprasidone hydrochloride. The proposed potentiometric methods offer the advantages of high-throughput determination, simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.

AB - The membranes of ziprasidone hydrochloride-tetraphenyl borate, (Zp-TPB), chlorophenyl borate (Zp-ClPB), phosphotungstate (Zp3-PT), ion associations as molecular recognition reagent dispersed in PVC matrix with dibutylphthalate as plasticizer have been proposed for quantification of ziprasidone hydrochloride. The performance characteristics revealed a fast, stable and liner response for ziprasidone over the concentration ranges of 8.5 × 10-6-1.0 × 10-2 M, 3.9 × 10-6-1.0 × 10-2M, 7.7 × 10-7-1.0 × 10-2 M ZpCl with cationic slopes of 57.0, 56.0, 58.5 mV/decade respectively. The solubility product of the ion-pair and the formation constant of the precipitation reaction leading to the ion-pair formation were determined conductometrically. The potentiometric determination of ziprasidone hydrochloride ion in different pharmaceutical preparations and biological fluids has been achieved without any interference from various excipients and diluents commonly used in drug formulations. Validation of the method shows suitability of the proposed electrodes for use in the quality control assessment of ziprasidone hydrochloride. The proposed potentiometric methods offer the advantages of high-throughput determination, simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.

KW - Ion-pair

KW - Membrane selective electrodes

KW - Neutral carriers

KW - Pharmaceutical analysis

KW - Solubility product

UR - https://www.scopus.com/pages/publications/79960507099

U2 - 10.1016/s1452-3981(23)18235-6

DO - 10.1016/s1452-3981(23)18235-6

M3 - Article

AN - SCOPUS:79960507099

SN - 1452-3981

VL - 6

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EP - 3056

JO - International Journal of Electrochemical Science

JF - International Journal of Electrochemical Science

IS - 7

ER -

Potentiometric assay of antipsychotic drug (Ziprasidone Hydrochloride) in pharmaceuticals, serum and urine

Abstract

Keywords

ASJC Scopus subject areas

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