Portable system of programmable syringe pump with potentiometer for determination of promethazine in pharmaceutical applications

Tawfik A. Saleh; A. M. Abulkibash; Atta E. Ibrahim

doi:10.1016/j.jsps.2011.08.005

Portable system of programmable syringe pump with potentiometer for determination of promethazine in pharmaceutical applications

Tawfik A. Saleh^*, A. M. Abulkibash, Atta E. Ibrahim

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A simple and fast-automated method was developed and validated for the assay of promethazine hydrochloride in pharmaceutical formulations, based on the oxidation of promethazine by cerium in an acidic medium. A portable system, consisting of a programmable syringe pump connected to a potentiometer, was constructed. The developed change in potential during promethazine oxidation was monitored. The related optimum working conditions, such as supporting electrolyte concentration, cerium(IV) concentration and flow rate were optimized. The proposed method was successfully applied to pharmaceutical samples as well as synthetic ones. The obtained results were realized by the official British pharmacopoeia (BP) method and comparable results were obtained. The obtained . t-value indicates no significant differences between the results of the proposed and BP methods, with the advantages of the proposed method being simple, sensitive and cost effective.

Original language	English
Pages (from-to)	155-160
Number of pages	6
Journal	Saudi Pharmaceutical Journal
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.jsps.2011.08.005
State	Published - Apr 2012

Bibliographical note

Funding Information:
The authors acknowledge the support of King Fahd University of Petroleum and Minerals, Chemistry department. The financial support of King Abdulaziz City for Science and Technology (KACST) under project APR -26-72 is also acknowledged.

Keywords

Pharmaceutical applications
Portable syringe pump
Potentiometry
Promethazine

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1016/j.jsps.2011.08.005

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@article{1a62dbf56acc4cfdae01dc01084e31c6,

title = "Portable system of programmable syringe pump with potentiometer for determination of promethazine in pharmaceutical applications",

abstract = "A simple and fast-automated method was developed and validated for the assay of promethazine hydrochloride in pharmaceutical formulations, based on the oxidation of promethazine by cerium in an acidic medium. A portable system, consisting of a programmable syringe pump connected to a potentiometer, was constructed. The developed change in potential during promethazine oxidation was monitored. The related optimum working conditions, such as supporting electrolyte concentration, cerium(IV) concentration and flow rate were optimized. The proposed method was successfully applied to pharmaceutical samples as well as synthetic ones. The obtained results were realized by the official British pharmacopoeia (BP) method and comparable results were obtained. The obtained . t-value indicates no significant differences between the results of the proposed and BP methods, with the advantages of the proposed method being simple, sensitive and cost effective.",

keywords = "Pharmaceutical applications, Portable syringe pump, Potentiometry, Promethazine",

author = "Saleh, \{Tawfik A.\} and Abulkibash, \{A. M.\} and Ibrahim, \{Atta E.\}",

note = "Funding Information: The authors acknowledge the support of King Fahd University of Petroleum and Minerals, Chemistry department. The financial support of King Abdulaziz City for Science and Technology (KACST) under project APR -26-72 is also acknowledged.",

year = "2012",

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doi = "10.1016/j.jsps.2011.08.005",

language = "English",

volume = "20",

pages = "155--160",

journal = "Saudi Pharmaceutical Journal",

issn = "1319-0164",

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T1 - Portable system of programmable syringe pump with potentiometer for determination of promethazine in pharmaceutical applications

AU - Saleh, Tawfik A.

AU - Abulkibash, A. M.

AU - Ibrahim, Atta E.

N1 - Funding Information: The authors acknowledge the support of King Fahd University of Petroleum and Minerals, Chemistry department. The financial support of King Abdulaziz City for Science and Technology (KACST) under project APR -26-72 is also acknowledged.

PY - 2012/4

Y1 - 2012/4

N2 - A simple and fast-automated method was developed and validated for the assay of promethazine hydrochloride in pharmaceutical formulations, based on the oxidation of promethazine by cerium in an acidic medium. A portable system, consisting of a programmable syringe pump connected to a potentiometer, was constructed. The developed change in potential during promethazine oxidation was monitored. The related optimum working conditions, such as supporting electrolyte concentration, cerium(IV) concentration and flow rate were optimized. The proposed method was successfully applied to pharmaceutical samples as well as synthetic ones. The obtained results were realized by the official British pharmacopoeia (BP) method and comparable results were obtained. The obtained . t-value indicates no significant differences between the results of the proposed and BP methods, with the advantages of the proposed method being simple, sensitive and cost effective.

AB - A simple and fast-automated method was developed and validated for the assay of promethazine hydrochloride in pharmaceutical formulations, based on the oxidation of promethazine by cerium in an acidic medium. A portable system, consisting of a programmable syringe pump connected to a potentiometer, was constructed. The developed change in potential during promethazine oxidation was monitored. The related optimum working conditions, such as supporting electrolyte concentration, cerium(IV) concentration and flow rate were optimized. The proposed method was successfully applied to pharmaceutical samples as well as synthetic ones. The obtained results were realized by the official British pharmacopoeia (BP) method and comparable results were obtained. The obtained . t-value indicates no significant differences between the results of the proposed and BP methods, with the advantages of the proposed method being simple, sensitive and cost effective.

KW - Pharmaceutical applications

KW - Portable syringe pump

KW - Potentiometry

KW - Promethazine

UR - https://www.scopus.com/pages/publications/84860328219

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DO - 10.1016/j.jsps.2011.08.005

M3 - Article

AN - SCOPUS:84860328219

SN - 1319-0164

VL - 20

SP - 155

EP - 160

JO - Saudi Pharmaceutical Journal

JF - Saudi Pharmaceutical Journal

IS - 2

ER -

Portable system of programmable syringe pump with potentiometer for determination of promethazine in pharmaceutical applications

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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