Abstract
In this work, a novel microextraction method termed polymer-coated hollow fiber microextraction (PC-HFME) was developed in combination with capillary electrophoresis (CE). Polar dihydroxylated polymethalmethacrylate polymer was coated onto a porous propylene hollow fiber membrane and used as an adsorbent and that was placed in a stirred aqueous sample solution. Tumbling of the extraction device within the sample solution facilitated extraction. The amino alcohols (2-amino-1-phenylethanol, norephedrine, alprenolol and atenolol which are β-blocker drugs), were used as model compounds to investigate the extraction performance. No organic solvent was used in this procedure. The extract was then further concentrated through on-column stacking (normal stacking mode) during CE analysis. The detection limits ranged from 0.9 to 7 ng ml-1. Relative standard deviations (n = 6) ranged from 4 to 6%. The extraction of the amino alcohols in spiked wastewater effluent (representing a complex matrix) was evaluated using the developed procedure.
| Original language | English |
|---|---|
| Pages (from-to) | 267-272 |
| Number of pages | 6 |
| Journal | Journal of Chromatography A |
| Volume | 1128 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 22 Sep 2006 |
| Externally published | Yes |
Bibliographical note
Funding Information:The authors gratefully acknowledge the financial support of this research by the Agency for Science, Technology and Research of Singapore, the National University of Singapore and the United Nations University, Tokyo, Japan.
Keywords
- Amino alcohols
- Capillary electrophoresis
- Functional polymers and hollow fiber
- Microextraction
- Stacking
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Organic Chemistry
