Polyamidoamine-Based Anticancer Therapies

Cancer is well known for creating destruction in current civilization despite remarkable progress in the area of medical technology. The ultimate objective is to eliminate the terrible disease that may require the investigation of novel molecules. Delivery concepts like viral carriers, peptides, PAMAM dendrimers, gold nanosystems, liposomes, and polymers are being analyzed during such investigations. With structural adaptability, polymer-grounded drug delivery systems offer biocompatibility and enhanced medicine circulation time. Polyamidoamine (PAMAM) dendrimers are a novel class of spherical, well-designed branching polymers with interior cavities and abundant terminal groups on the surface, which can form stable complexes with drugs, plasmid DNA, oligonucleotides, and antibodies. PAMAM dendrimers can be engineered with various functional groups for specific targeting ability, and are appealing groups of medicines and gene transfer vectors. The highly attractive feature of modifiable multiple surface functionalities facilitates the conjugation of various ligands for cancer targeting, imaging, and therapy. This chapter describes PAMAM dendrimer-based multicomponent therapeutic agents for treating different types of cancers. Polymers like polyamidoamine dendrimers perform an important function in the designing and discovery of medicines. For a few decades, gene treatment has been prevailing in clinical trials. A well-planned carrier is the most preferable method for enhancing the safety of gene therapy.