Phase behavior study of paclitaxel loaded amphiphilic copolymer in two solvents by dissipative particle dynamics simulations

Xin Dong Guo; Jeremy Pang Kern Tan; Li Juan Zhang; Majad Khan; Shao Qiong Liu; Yi Yan Yang; Yu Qian

doi:10.1016/j.cplett.2009.04.009

Phase behavior study of paclitaxel loaded amphiphilic copolymer in two solvents by dissipative particle dynamics simulations

Xin Dong Guo, Jeremy Pang Kern Tan, Li Juan Zhang, Majad Khan, Shao Qiong Liu, Yi Yan Yang^*, Yu Qian

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

DPD simulations were employed to study the phase behavior of paclitaxel loaded PEO₁₁-b-PLLA₉ in water and N,N-Dimethylformamide. Different ordered structures were observed in water-rich solvents. All the structures were greatly affected by solvents compositions. By varying the fractions of each component, a phase diagram of paclitaxel loaded PEO₁₁-b-PLLA₉ in water and DMF was mapped. For all ordered structures, bicontinuous, lamella, rod, and spherical structures with different sizes could be easily observed for their wide distribution in the phase diagram. While the HPL, dumbbell, and spherical structures with uniform size were difficult to be obtained, due to their narrow distribution.

Original language	English
Pages (from-to)	336-342
Number of pages	7
Journal	Chemical Physics Letters
Volume	473
Issue number	4-6
DOIs	https://doi.org/10.1016/j.cplett.2009.04.009
State	Published - 12 May 2009
Externally published	Yes

Bibliographical note

Funding Information:
This work was financially supported by National Natural Science Foundation of China (Nos. 20536020 and 20776049) and Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research, Singapore. The first author also appreciates the China Scholarship Council’s support for his visiting study at IBN.

ASJC Scopus subject areas

General Physics and Astronomy
Physical and Theoretical Chemistry

Access to Document

10.1016/j.cplett.2009.04.009

Cite this

@article{06be3b4c20fe45369a5d1e3358301e52,

title = "Phase behavior study of paclitaxel loaded amphiphilic copolymer in two solvents by dissipative particle dynamics simulations",

abstract = "DPD simulations were employed to study the phase behavior of paclitaxel loaded PEO11-b-PLLA9 in water and N,N-Dimethylformamide. Different ordered structures were observed in water-rich solvents. All the structures were greatly affected by solvents compositions. By varying the fractions of each component, a phase diagram of paclitaxel loaded PEO11-b-PLLA9 in water and DMF was mapped. For all ordered structures, bicontinuous, lamella, rod, and spherical structures with different sizes could be easily observed for their wide distribution in the phase diagram. While the HPL, dumbbell, and spherical structures with uniform size were difficult to be obtained, due to their narrow distribution.",

author = "Guo, {Xin Dong} and Tan, {Jeremy Pang Kern} and Zhang, {Li Juan} and Majad Khan and Liu, {Shao Qiong} and Yang, {Yi Yan} and Yu Qian",

note = "Funding Information: This work was financially supported by National Natural Science Foundation of China (Nos. 20536020 and 20776049) and Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research, Singapore. The first author also appreciates the China Scholarship Council{\textquoteright}s support for his visiting study at IBN. ",

year = "2009",

month = may,

day = "12",

doi = "10.1016/j.cplett.2009.04.009",

language = "English",

volume = "473",

pages = "336--342",

journal = "Chemical Physics Letters",

issn = "0009-2614",

number = "4-6",

}

TY - JOUR

T1 - Phase behavior study of paclitaxel loaded amphiphilic copolymer in two solvents by dissipative particle dynamics simulations

AU - Guo, Xin Dong

AU - Tan, Jeremy Pang Kern

AU - Zhang, Li Juan

AU - Khan, Majad

AU - Liu, Shao Qiong

AU - Yang, Yi Yan

AU - Qian, Yu

N1 - Funding Information: This work was financially supported by National Natural Science Foundation of China (Nos. 20536020 and 20776049) and Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research, Singapore. The first author also appreciates the China Scholarship Council’s support for his visiting study at IBN.

PY - 2009/5/12

Y1 - 2009/5/12

N2 - DPD simulations were employed to study the phase behavior of paclitaxel loaded PEO11-b-PLLA9 in water and N,N-Dimethylformamide. Different ordered structures were observed in water-rich solvents. All the structures were greatly affected by solvents compositions. By varying the fractions of each component, a phase diagram of paclitaxel loaded PEO11-b-PLLA9 in water and DMF was mapped. For all ordered structures, bicontinuous, lamella, rod, and spherical structures with different sizes could be easily observed for their wide distribution in the phase diagram. While the HPL, dumbbell, and spherical structures with uniform size were difficult to be obtained, due to their narrow distribution.

AB - DPD simulations were employed to study the phase behavior of paclitaxel loaded PEO11-b-PLLA9 in water and N,N-Dimethylformamide. Different ordered structures were observed in water-rich solvents. All the structures were greatly affected by solvents compositions. By varying the fractions of each component, a phase diagram of paclitaxel loaded PEO11-b-PLLA9 in water and DMF was mapped. For all ordered structures, bicontinuous, lamella, rod, and spherical structures with different sizes could be easily observed for their wide distribution in the phase diagram. While the HPL, dumbbell, and spherical structures with uniform size were difficult to be obtained, due to their narrow distribution.

UR - http://www.scopus.com/inward/record.url?scp=65149106082&partnerID=8YFLogxK

U2 - 10.1016/j.cplett.2009.04.009

DO - 10.1016/j.cplett.2009.04.009

M3 - Article

AN - SCOPUS:65149106082

SN - 0009-2614

VL - 473

SP - 336

EP - 342

JO - Chemical Physics Letters

JF - Chemical Physics Letters

IS - 4-6

ER -

Phase behavior study of paclitaxel loaded amphiphilic copolymer in two solvents by dissipative particle dynamics simulations

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this