Pd-Catalyzed regio- And enantioselective allylic substitution with 2-pyridones

Sardaraz Khan; Babar Hussain Shah; Ijaz Khan; Meiqi Li; Yong Jian Zhang

doi:10.1039/c9cc07482a

Pd-Catalyzed regio- And enantioselective allylic substitution with 2-pyridones

Sardaraz Khan, Babar Hussain Shah, Ijaz Khan, Meiqi Li, Yong Jian Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

An efficient method for the asymmetric synthesis of N-substituted 2-pyridones via Pd-catalyzed regio- and enantioselective allylic substitution of hydroxyl-containing allylic carbonates with 2-pyridones has been developed. By using a palladium complex in situ generated from Pd₂(dba)₃·CHCl₃ and phosphoramidite L2 as a ligand, the process allowed rapid access to N-substituted 2-pyridones with complete chemo- and regioselectivities and good to high enantioselectivities.

Original language	English
Pages (from-to)	13168-13171
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	87
DOIs	https://doi.org/10.1039/c9cc07482a
State	Published - 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Pd-Catalyzed regio- And enantioselective allylic substitution with 2-pyridones",

abstract = "An efficient method for the asymmetric synthesis of N-substituted 2-pyridones via Pd-catalyzed regio- and enantioselective allylic substitution of hydroxyl-containing allylic carbonates with 2-pyridones has been developed. By using a palladium complex in situ generated from Pd2(dba)3·CHCl3 and phosphoramidite L2 as a ligand, the process allowed rapid access to N-substituted 2-pyridones with complete chemo- and regioselectivities and good to high enantioselectivities.",

author = "Sardaraz Khan and Shah, {Babar Hussain} and Ijaz Khan and Meiqi Li and Zhang, {Yong Jian}",

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year = "2019",

doi = "10.1039/c9cc07482a",

language = "English",

volume = "55",

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T1 - Pd-Catalyzed regio- And enantioselective allylic substitution with 2-pyridones

AU - Khan, Sardaraz

AU - Shah, Babar Hussain

AU - Khan, Ijaz

AU - Li, Meiqi

AU - Zhang, Yong Jian

PY - 2019

Y1 - 2019

N2 - An efficient method for the asymmetric synthesis of N-substituted 2-pyridones via Pd-catalyzed regio- and enantioselective allylic substitution of hydroxyl-containing allylic carbonates with 2-pyridones has been developed. By using a palladium complex in situ generated from Pd2(dba)3·CHCl3 and phosphoramidite L2 as a ligand, the process allowed rapid access to N-substituted 2-pyridones with complete chemo- and regioselectivities and good to high enantioselectivities.

AB - An efficient method for the asymmetric synthesis of N-substituted 2-pyridones via Pd-catalyzed regio- and enantioselective allylic substitution of hydroxyl-containing allylic carbonates with 2-pyridones has been developed. By using a palladium complex in situ generated from Pd2(dba)3·CHCl3 and phosphoramidite L2 as a ligand, the process allowed rapid access to N-substituted 2-pyridones with complete chemo- and regioselectivities and good to high enantioselectivities.

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U2 - 10.1039/c9cc07482a

DO - 10.1039/c9cc07482a

M3 - Article

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AN - SCOPUS:85074242246

SN - 1359-7345

VL - 55

SP - 13168

EP - 13171

JO - Chemical Communications

JF - Chemical Communications

IS - 87

ER -

Pd-Catalyzed regio- And enantioselective allylic substitution with 2-pyridones

Abstract

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ASJC Scopus subject areas

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