Palladium-catalyzed carbonylative synthesis of N-(2-cyanoaryl)benzamides and sequential synthesis of quinazolinones

Xiao Feng Wu; Stefan Oschatz; Muhammad Sharif; Matthias Beller; Peter Langer

doi:10.1016/j.tet.2013.11.055

Palladium-catalyzed carbonylative synthesis of N-(2-cyanoaryl)benzamides and sequential synthesis of quinazolinones

Xiao Feng Wu^*
, Stefan Oschatz
, Muhammad Sharif
, Matthias Beller
, Peter Langer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

A convenient procedure for the synthesis of N-(2-cyanoaryl)benzamides has been developed. Using aryl bromides and 2-aminobenzonitriles as the substrates, Mo(CO)₆ as the CO source, the desired amides were produced in good yields. Quinazolinones were produced in good yields in a sequential manner as well.

Original language	English
Pages (from-to)	23-29
Number of pages	7
Journal	Tetrahedron
Volume	70
Issue number	1
DOIs	https://doi.org/10.1016/j.tet.2013.11.055
State	Published - 7 Jan 2014
Externally published	Yes

Bibliographical note

Funding Information:
The authors thank the state of Mecklenburg-Vorpommern and the Bundesministerium für Bildung und Forschung (BMBF) for financial support. We also thank Drs. W. Baumann, C. Fischer, Ms. S. Schareina and Ms. S. Buchholz (LIKAT) for analytical support.

Keywords

Amide
Carbonylation
Mo(CO)
Palladium catalyst
Quinazolinone

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Palladium-catalyzed carbonylative synthesis of N-(2-cyanoaryl)benzamides and sequential synthesis of quinazolinones",

abstract = "A convenient procedure for the synthesis of N-(2-cyanoaryl)benzamides has been developed. Using aryl bromides and 2-aminobenzonitriles as the substrates, Mo(CO)6 as the CO source, the desired amides were produced in good yields. Quinazolinones were produced in good yields in a sequential manner as well.",

keywords = "Amide, Carbonylation, Mo(CO), Palladium catalyst, Quinazolinone",

author = "Wu, \{Xiao Feng\} and Stefan Oschatz and Muhammad Sharif and Matthias Beller and Peter Langer",

note = "Funding Information: The authors thank the state of Mecklenburg-Vorpommern and the Bundesministerium f{\"u}r Bildung und Forschung (BMBF) for financial support. We also thank Drs. W. Baumann, C. Fischer, Ms. S. Schareina and Ms. S. Buchholz (LIKAT) for analytical support. ",

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doi = "10.1016/j.tet.2013.11.055",

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T1 - Palladium-catalyzed carbonylative synthesis of N-(2-cyanoaryl)benzamides and sequential synthesis of quinazolinones

AU - Wu, Xiao Feng

AU - Oschatz, Stefan

AU - Sharif, Muhammad

AU - Beller, Matthias

AU - Langer, Peter

N1 - Funding Information: The authors thank the state of Mecklenburg-Vorpommern and the Bundesministerium für Bildung und Forschung (BMBF) for financial support. We also thank Drs. W. Baumann, C. Fischer, Ms. S. Schareina and Ms. S. Buchholz (LIKAT) for analytical support.

PY - 2014/1/7

Y1 - 2014/1/7

N2 - A convenient procedure for the synthesis of N-(2-cyanoaryl)benzamides has been developed. Using aryl bromides and 2-aminobenzonitriles as the substrates, Mo(CO)6 as the CO source, the desired amides were produced in good yields. Quinazolinones were produced in good yields in a sequential manner as well.

AB - A convenient procedure for the synthesis of N-(2-cyanoaryl)benzamides has been developed. Using aryl bromides and 2-aminobenzonitriles as the substrates, Mo(CO)6 as the CO source, the desired amides were produced in good yields. Quinazolinones were produced in good yields in a sequential manner as well.

KW - Amide

KW - Carbonylation

KW - Mo(CO)

KW - Palladium catalyst

KW - Quinazolinone

UR - https://www.scopus.com/pages/publications/84889666105

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DO - 10.1016/j.tet.2013.11.055

M3 - Article

AN - SCOPUS:84889666105

SN - 0040-4020

VL - 70

SP - 23

EP - 29

JO - Tetrahedron

JF - Tetrahedron

IS - 1

ER -

Palladium-catalyzed carbonylative synthesis of N-(2-cyanoaryl)benzamides and sequential synthesis of quinazolinones

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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