Abstract
An efficient method for the diastereo- and enantioselective construction of tetrahydrofurans bearing three continuous stereocenters including vicinal tetrasubstituted stereocenters via palladium-catalyzed asymmetric allylic cycloaddition of vinylethylene carbonates with nitroalkenes was developed. By using a palladium complex generated in situ from [Pd2(dba)3] ⋅ CHCl3 and (R)-BINAP ligand as a catalyst under mild reaction conditions, the process provides multi-functionalized tetrahydrofurans in good yields with excellent stereoselectivities.
| Original language | English |
|---|---|
| Article number | e202200313 |
| Journal | Asian Journal of Organic Chemistry |
| Volume | 11 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2022 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2022 Wiley-VCH GmbH.
Keywords
- allylic cycloaddition
- asymmetric catalysis
- multi-substituted tetrahydrofurans
- palladium-catalyzed reaction
- quaternary stereocenters
ASJC Scopus subject areas
- Organic Chemistry
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