Palladium-catalysed Suzuki-Miyaura coupling reactions of Bromhexine and Ambroxol

Muhammad Sharif; Anahit Pews-Davtyan; Jan Lukas; Susann Pohlers; Arndt Rolfs; Peter Langer; Matthias Beller

doi:10.1016/j.tet.2014.05.116

Palladium-catalysed Suzuki-Miyaura coupling reactions of Bromhexine and Ambroxol

Muhammad Sharif
, Anahit Pews-Davtyan
, Jan Lukas
, Susann Pohlers
, Arndt Rolfs^*
, Peter Langer
, Matthias Beller

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The Suzuki-Miyaura coupling reaction was applied for the synthesis of biologically relevant derivatives of known mucolytic agents Bromhexine and Ambroxol. Using commercially available electron-rich and electron-poor arylboronic acids the desired products are obtained in moderate to high yields (42-81%).

Original language	English
Pages (from-to)	5128-5135
Number of pages	8
Journal	Tetrahedron
Volume	70
Issue number	34
DOIs	https://doi.org/10.1016/j.tet.2014.05.116
State	Published - 26 Aug 2014
Externally published	Yes

Bibliographical note

Funding Information:
We thank the State of Mecklenburg-Western Pomerania , the Bundesministerium für Bildung und Forschung , the Deutsche Forschungsgemeinschaft (Graduiertenkolleg 1213 and Leibniz prize) and the Fonds der Chemischen Industrie for financial support. We thank our analytical department for their excellent technical and analytical support.

Keywords

Ambroxol
Bromhexine
Catalysis
Palladium
Suzuki-Miyaura

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2014.05.116

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title = "Palladium-catalysed Suzuki-Miyaura coupling reactions of Bromhexine and Ambroxol",

abstract = "The Suzuki-Miyaura coupling reaction was applied for the synthesis of biologically relevant derivatives of known mucolytic agents Bromhexine and Ambroxol. Using commercially available electron-rich and electron-poor arylboronic acids the desired products are obtained in moderate to high yields (42-81\%).",

keywords = "Ambroxol, Bromhexine, Catalysis, Palladium, Suzuki-Miyaura",

author = "Muhammad Sharif and Anahit Pews-Davtyan and Jan Lukas and Susann Pohlers and Arndt Rolfs and Peter Langer and Matthias Beller",

note = "Funding Information: We thank the State of Mecklenburg-Western Pomerania , the Bundesministerium f{\"u}r Bildung und Forschung , the Deutsche Forschungsgemeinschaft (Graduiertenkolleg 1213 and Leibniz prize) and the Fonds der Chemischen Industrie for financial support. We thank our analytical department for their excellent technical and analytical support. ",

year = "2014",

month = aug,

day = "26",

doi = "10.1016/j.tet.2014.05.116",

language = "English",

volume = "70",

pages = "5128--5135",

journal = "Tetrahedron",

issn = "0040-4020",

number = "34",

}

TY - JOUR

T1 - Palladium-catalysed Suzuki-Miyaura coupling reactions of Bromhexine and Ambroxol

AU - Sharif, Muhammad

AU - Pews-Davtyan, Anahit

AU - Lukas, Jan

AU - Pohlers, Susann

AU - Rolfs, Arndt

AU - Langer, Peter

AU - Beller, Matthias

N1 - Funding Information: We thank the State of Mecklenburg-Western Pomerania , the Bundesministerium für Bildung und Forschung , the Deutsche Forschungsgemeinschaft (Graduiertenkolleg 1213 and Leibniz prize) and the Fonds der Chemischen Industrie for financial support. We thank our analytical department for their excellent technical and analytical support.

PY - 2014/8/26

Y1 - 2014/8/26

N2 - The Suzuki-Miyaura coupling reaction was applied for the synthesis of biologically relevant derivatives of known mucolytic agents Bromhexine and Ambroxol. Using commercially available electron-rich and electron-poor arylboronic acids the desired products are obtained in moderate to high yields (42-81%).

AB - The Suzuki-Miyaura coupling reaction was applied for the synthesis of biologically relevant derivatives of known mucolytic agents Bromhexine and Ambroxol. Using commercially available electron-rich and electron-poor arylboronic acids the desired products are obtained in moderate to high yields (42-81%).

KW - Ambroxol

KW - Bromhexine

KW - Catalysis

KW - Palladium

KW - Suzuki-Miyaura

UR - https://www.scopus.com/pages/publications/84903378399

U2 - 10.1016/j.tet.2014.05.116

DO - 10.1016/j.tet.2014.05.116

M3 - Article

AN - SCOPUS:84903378399

SN - 0040-4020

VL - 70

SP - 5128

EP - 5135

JO - Tetrahedron

JF - Tetrahedron

IS - 34

ER -

Palladium-catalysed Suzuki-Miyaura coupling reactions of Bromhexine and Ambroxol

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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