Palladium-Based Nanocatalyst for One-Pot Synthesis of Polysubstituted Quinolines

Benjamin Wei Jie Chen; Leng Leng Chng; Jun Yang; Yifeng Wei; Jinhua Yang; Jackie Y. Ying

doi:10.1002/cctc.201200496

Palladium-Based Nanocatalyst for One-Pot Synthesis of Polysubstituted Quinolines

Benjamin Wei Jie Chen
, Leng Leng Chng
, Jun Yang
, Yifeng Wei
, Jinhua Yang
, Jackie Y. Ying^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

The synthesis of quinolines has been achieved through a one-pot, two-step tandem reaction catalyzed with Ag-Pd alloy nanoparticles supported on carbon. Ag-Pd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields α-alkylated ketones under an Ar flow. These are reacted with 2-aminobenzyl alcohols in a modified Friedländer synthesis to give polysubstituted quinolines in moderate to good yields.

Original language	English
Pages (from-to)	277-283
Number of pages	7
Journal	ChemCatChem
Volume	5
Issue number	1
DOIs	https://doi.org/10.1002/cctc.201200496
State	Published - Jan 2013
Externally published	Yes

Keywords

Heterogeneous catalysis
Nanomaterial
One-pot reaction
Palladium
Quinoline

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1002/cctc.201200496

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title = "Palladium-Based Nanocatalyst for One-Pot Synthesis of Polysubstituted Quinolines",

abstract = "The synthesis of quinolines has been achieved through a one-pot, two-step tandem reaction catalyzed with Ag-Pd alloy nanoparticles supported on carbon. Ag-Pd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields α-alkylated ketones under an Ar flow. These are reacted with 2-aminobenzyl alcohols in a modified Friedl{\"a}nder synthesis to give polysubstituted quinolines in moderate to good yields.",

keywords = "Heterogeneous catalysis, Nanomaterial, One-pot reaction, Palladium, Quinoline",

author = "Chen, \{Benjamin Wei Jie\} and Chng, \{Leng Leng\} and Jun Yang and Yifeng Wei and Jinhua Yang and Ying, \{Jackie Y.\}",

year = "2013",

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doi = "10.1002/cctc.201200496",

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journal = "ChemCatChem",

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T1 - Palladium-Based Nanocatalyst for One-Pot Synthesis of Polysubstituted Quinolines

AU - Chen, Benjamin Wei Jie

AU - Chng, Leng Leng

AU - Yang, Jun

AU - Wei, Yifeng

AU - Yang, Jinhua

AU - Ying, Jackie Y.

PY - 2013/1

Y1 - 2013/1

N2 - The synthesis of quinolines has been achieved through a one-pot, two-step tandem reaction catalyzed with Ag-Pd alloy nanoparticles supported on carbon. Ag-Pd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields α-alkylated ketones under an Ar flow. These are reacted with 2-aminobenzyl alcohols in a modified Friedländer synthesis to give polysubstituted quinolines in moderate to good yields.

AB - The synthesis of quinolines has been achieved through a one-pot, two-step tandem reaction catalyzed with Ag-Pd alloy nanoparticles supported on carbon. Ag-Pd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields α-alkylated ketones under an Ar flow. These are reacted with 2-aminobenzyl alcohols in a modified Friedländer synthesis to give polysubstituted quinolines in moderate to good yields.

KW - Heterogeneous catalysis

KW - Nanomaterial

KW - One-pot reaction

KW - Palladium

KW - Quinoline

UR - https://www.scopus.com/pages/publications/84871658691

U2 - 10.1002/cctc.201200496

DO - 10.1002/cctc.201200496

M3 - Article

AN - SCOPUS:84871658691

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VL - 5

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EP - 283

JO - ChemCatChem

JF - ChemCatChem

IS - 1

ER -

Palladium-Based Nanocatalyst for One-Pot Synthesis of Polysubstituted Quinolines

Abstract

Keywords

ASJC Scopus subject areas

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