Optimization of DNA detection using FETs

M. Waleed Shinwari, M. Jamal Deen

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Direct electrical detection of DNA using field-effect transistors (FETs) has proven to facilitate the development of robust biosensors that are CMOS-compatible and highly sensitive. In this paper, we identify several factors that can cause the performance of different BioFET cells in an array to differ, causing unwanted background variations between the cells of a microarray. These variations add up to the already existing noise sources, such as the electrolyte noise, the FET noise, and the reference electrode drift. We also introduce techniques that can potentially speed up the hybridization process, reduce the noise, and enhance the sensitivity.

Original languageEnglish
Title of host publication1st Microsystems and Nanoelectronics Research Conference, MNRC 2008 - Enabling Synergy and Accelerating Excellence in Graduate Student Research
Pages185-188
Number of pages4
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

Name1st Microsystems and Nanoelectronics Research Conference, MNRC 2008 - Enabling Synergy and Accelerating Excellence in Graduate Student Research

Keywords

  • BioFET
  • Biomedical
  • CMOS
  • DNA
  • Microarray
  • Microfluidics
  • Sensor

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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