One-pot synthesis of three-dimensional Mn3O4 microcubes for high-level sensitive detection of head and neck cancer drug nimorazole

Rajaji Umamaheswari; Muthumariappan Akilarasan; Shen Ming Chen; Yi Hui Cheng; Veerappan Mani; Sakthivel Kogularasu; Fahad M.A. Al-Hemaid; M. Ajmal Ali; Xiaoheng Liu

doi:10.1016/j.jcis.2017.07.006

One-pot synthesis of three-dimensional Mn₃O₄ microcubes for high-level sensitive detection of head and neck cancer drug nimorazole

Rajaji Umamaheswari, Muthumariappan Akilarasan, Shen Ming Chen^*, Yi Hui Cheng, Veerappan Mani, Sakthivel Kogularasu, Fahad M.A. Al-Hemaid, M. Ajmal Ali, Xiaoheng Liu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We described a three-dimensional Mn₃O₄ microcubes (3D–Mn₃O₄MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D–Mn₃O₄ MCs possess large active area and high conductivity, and 3D–Mn₃O₄ MCs film modified screen-printed carbon electrode (3D–Mn₃O₄MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025–8060 µM concentration range and the detection limit was 6 nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations.

Original language	English
Pages (from-to)	1193-1201
Number of pages	9
Journal	Journal of Colloid and Interface Science
Volume	505
DOIs	https://doi.org/10.1016/j.jcis.2017.07.006
State	Published - 1 Nov 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.

Keywords

Anti-cancer drug
Biosensor
Drug analysis
Electrochemical biosensor
Modified electrode
Nimorazole
Transition metal oxides

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Surfaces, Coatings and Films
Colloid and Surface Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jcis.2017.07.006

Cite this

Umamaheswari, R., Akilarasan, M., Chen, S. M., Cheng, Y. H., Mani, V., Kogularasu, S., Al-Hemaid, F. M. A., Ajmal Ali, M., & Liu, X. (2017). One-pot synthesis of three-dimensional Mn₃O₄ microcubes for high-level sensitive detection of head and neck cancer drug nimorazole. Journal of Colloid and Interface Science, 505, 1193-1201. https://doi.org/10.1016/j.jcis.2017.07.006

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title = "One-pot synthesis of three-dimensional Mn3O4 microcubes for high-level sensitive detection of head and neck cancer drug nimorazole",

abstract = "We described a three-dimensional Mn3O4 microcubes (3D–Mn3O4MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D–Mn3O4 MCs possess large active area and high conductivity, and 3D–Mn3O4 MCs film modified screen-printed carbon electrode (3D–Mn3O4MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025–8060 µM concentration range and the detection limit was 6 nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations.",

keywords = "Anti-cancer drug, Biosensor, Drug analysis, Electrochemical biosensor, Modified electrode, Nimorazole, Transition metal oxides",

author = "Rajaji Umamaheswari and Muthumariappan Akilarasan and Chen, {Shen Ming} and Cheng, {Yi Hui} and Veerappan Mani and Sakthivel Kogularasu and Al-Hemaid, {Fahad M.A.} and {Ajmal Ali}, M. and Xiaoheng Liu",

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doi = "10.1016/j.jcis.2017.07.006",

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AU - Umamaheswari, Rajaji

AU - Akilarasan, Muthumariappan

AU - Chen, Shen Ming

AU - Cheng, Yi Hui

AU - Mani, Veerappan

AU - Kogularasu, Sakthivel

AU - Al-Hemaid, Fahad M.A.

AU - Ajmal Ali, M.

AU - Liu, Xiaoheng

PY - 2017/11/1

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N2 - We described a three-dimensional Mn3O4 microcubes (3D–Mn3O4MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D–Mn3O4 MCs possess large active area and high conductivity, and 3D–Mn3O4 MCs film modified screen-printed carbon electrode (3D–Mn3O4MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025–8060 µM concentration range and the detection limit was 6 nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations.

AB - We described a three-dimensional Mn3O4 microcubes (3D–Mn3O4MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D–Mn3O4 MCs possess large active area and high conductivity, and 3D–Mn3O4 MCs film modified screen-printed carbon electrode (3D–Mn3O4MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025–8060 µM concentration range and the detection limit was 6 nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations.

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KW - Biosensor

KW - Drug analysis

KW - Electrochemical biosensor

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