One-pot synthesis of difluorinated ortho -terphenyls by site-selective suzuki-miyaura reactions of 1,2-dibromo-3,5-difluorobenzene

The Suzuki-Miyaura reaction of 1,2-dibromo-3,5-difluorobenzene with two equivalents of arylboronic acids gave difluorinated ortho-terphenyls. The reaction with one equivalent of arylboronic acid resulted in site-selective formation of 2-bromo-3,5-difluoro-biphenyls. The one-pot reaction of 1,2-dibromo-3,5-difluorobenzene with two different arylboronic acids afforded difluorinated ortho-terphenyls containing two different terminal aryl groups.