Oligocephlate, a new α-glucosidase inhibitory neohopane triterpene from Vernonia oligocephala

Naheed Riaz; Kanwal Feroze; Muhammad Saleem; Sara Musaddiq; Muhammad Ashraf; Umber Alam; Rizwana Mustafa; Bushra Jabeen; Irshad Ahmad; Abdul Jabbar

Oligocephlate, a new α-glucosidase inhibitory neohopane triterpene from Vernonia oligocephala

Naheed Riaz^*, Kanwal Feroze, Muhammad Saleem, Sara Musaddiq, Muhammad Ashraf, Umber Alam, Rizwana Mustafa, Bushra Jabeen, Irshad Ahmad, Abdul Jabbar

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Oligocephlate (1), a new neohopane triterpene together with β-sitosterol (2), lupeol (3), oleanolic acid (4) and β-sitosterol-3-O- β-D-glucopyranoside (5) were isolated from the n-hexane soluble fraction of the methanolic extract of the whole plant of vernonia oligocephala. The structures of these compounds (1-5) were established by using 1D NMR ( ¹H and ¹³C) and 2D NMR (HMQC, HMBC, COSY, NOESY) spectroscopy and mass spectrometry (EIMS, HREIMS). Compound 1 showed inhibitory activity against enzyme α-glucosidase with IC₅₀ value 18.5 μM.

Original language	English
Pages (from-to)	972-975
Number of pages	4
Journal	Journal of the Chemical Society of Pakistan
Volume	35
Issue number	3
State	Published - Jun 2013
Externally published	Yes

Keywords

Asteraceae
Secondary metabolite
Triterpene
Vernonia oligocephala
α-glucosidase Inhibition

ASJC Scopus subject areas

General Chemistry

Cite this

@article{307d31fbdf5849fc8b77421722749970,

title = "Oligocephlate, a new α-glucosidase inhibitory neohopane triterpene from Vernonia oligocephala",

abstract = "Oligocephlate (1), a new neohopane triterpene together with β-sitosterol (2), lupeol (3), oleanolic acid (4) and β-sitosterol-3-O- β-D-glucopyranoside (5) were isolated from the n-hexane soluble fraction of the methanolic extract of the whole plant of vernonia oligocephala. The structures of these compounds (1-5) were established by using 1D NMR ( 1H and 13C) and 2D NMR (HMQC, HMBC, COSY, NOESY) spectroscopy and mass spectrometry (EIMS, HREIMS). Compound 1 showed inhibitory activity against enzyme α-glucosidase with IC50 value 18.5 μM.",

keywords = "Asteraceae, Secondary metabolite, Triterpene, Vernonia oligocephala, α-glucosidase Inhibition",

author = "Naheed Riaz and Kanwal Feroze and Muhammad Saleem and Sara Musaddiq and Muhammad Ashraf and Umber Alam and Rizwana Mustafa and Bushra Jabeen and Irshad Ahmad and Abdul Jabbar",

year = "2013",

month = jun,

language = "English",

volume = "35",

pages = "972--975",

journal = "Journal of the Chemical Society of Pakistan",

issn = "0253-5106",

number = "3",

}

TY - JOUR

T1 - Oligocephlate, a new α-glucosidase inhibitory neohopane triterpene from Vernonia oligocephala

AU - Riaz, Naheed

AU - Feroze, Kanwal

AU - Saleem, Muhammad

AU - Musaddiq, Sara

AU - Ashraf, Muhammad

AU - Alam, Umber

AU - Mustafa, Rizwana

AU - Jabeen, Bushra

AU - Ahmad, Irshad

AU - Jabbar, Abdul

PY - 2013/6

Y1 - 2013/6

N2 - Oligocephlate (1), a new neohopane triterpene together with β-sitosterol (2), lupeol (3), oleanolic acid (4) and β-sitosterol-3-O- β-D-glucopyranoside (5) were isolated from the n-hexane soluble fraction of the methanolic extract of the whole plant of vernonia oligocephala. The structures of these compounds (1-5) were established by using 1D NMR ( 1H and 13C) and 2D NMR (HMQC, HMBC, COSY, NOESY) spectroscopy and mass spectrometry (EIMS, HREIMS). Compound 1 showed inhibitory activity against enzyme α-glucosidase with IC50 value 18.5 μM.

AB - Oligocephlate (1), a new neohopane triterpene together with β-sitosterol (2), lupeol (3), oleanolic acid (4) and β-sitosterol-3-O- β-D-glucopyranoside (5) were isolated from the n-hexane soluble fraction of the methanolic extract of the whole plant of vernonia oligocephala. The structures of these compounds (1-5) were established by using 1D NMR ( 1H and 13C) and 2D NMR (HMQC, HMBC, COSY, NOESY) spectroscopy and mass spectrometry (EIMS, HREIMS). Compound 1 showed inhibitory activity against enzyme α-glucosidase with IC50 value 18.5 μM.

KW - Asteraceae

KW - Secondary metabolite

KW - Triterpene

KW - Vernonia oligocephala

KW - α-glucosidase Inhibition

UR - https://www.scopus.com/pages/publications/84879735940

M3 - Article

AN - SCOPUS:84879735940

SN - 0253-5106

VL - 35

SP - 972

EP - 975

JO - Journal of the Chemical Society of Pakistan

JF - Journal of the Chemical Society of Pakistan

IS - 3

ER -

Oligocephlate, a new α-glucosidase inhibitory neohopane triterpene from Vernonia oligocephala

Abstract

Keywords

ASJC Scopus subject areas

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