Novel statistical time series data augmentation and machine learning based classification of unobtrusive respiration data for respiration Digital Twin model

Digital Twin (DT), a concept of Healthcare (4.0), represents the subject's biological properties and characteristics in a digital model. DT can help in monitoring respiratory failures, enabling timely interventions, personalized treatment plans to improve healthcare, and decision-support for healthcare professionals. Large-scale implementation of DT technology requires extensive patient data for accurate monitoring and decision-making with Machine Learning (ML) and Deep Learning (DL). Initial respiration data was collected unobtrusively with the ESP32 Wi-Fi Channel State Information (CSI) sensor. Due to limited respiration data availability, the paper proposes a novel statistical time series data augmentation method for generating larger synthetic respiration data. To ensure accuracy and validity in the augmentation method, correlation methods (Pearson, Spearman, and Kendall) are implemented to provide a comparative analysis of experimental and synthetic datasets. Data processing methodologies of denoising (smoothing and filtering) and dimensionality reduction with Principal Component Analysis (PCA) are implemented to estimate a patient's Breaths Per Minute (BPM) from raw respiration sensor data and the synthetic version. The methodology provided the BPM estimation accuracy of 92.3% from raw respiration data. It was observed that out of 27 supervised classifications with k-fold cross-validation, the Bagged Tree ensemble algorithm provided the best ML-supervised classification. In the case of binary-class and multi-class, the Bagged Tree ensemble showed accuracies of 89.2% and 83.7% respectively with combined real and synthetic respiration dataset with the larger synthetic dataset. Overall, this provides a blueprint of methodologies for the development of the respiration DT model.