Notes. Complexation of gold(I) thiomalate ('myocrisin') with 1,3-diazinane-2-thione in aqueous solution followed by 13C nuclear magnetic resonance spectroscopy

Anvarhusein A. Isab

doi:10.1039/DT9860001049

Notes. Complexation of gold(I) thiomalate ('myocrisin') with 1,3-diazinane-2-thione in aqueous solution followed by ¹³C nuclear magnetic resonance spectroscopy

Anvarhusein A. Isab^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The interaction of gold(I) thiomalate ('Myocrisin'; an anti-arthritic drug) [Au(tm)] with 1,3-diazinane-2-thione (L) has been studied in aqueous solution at pH * 7.2 by using ¹³C n.m.r. spectroscopy. It is found that [Au(tm)] forms a 1:1 complex of tm-Au-L. In the presence of excess thiomalate, L is displaced as a free ligand in solution suggesting that a thiol binds to gold(I) more strongly than does a thione.

Original language	English
Pages (from-to)	1049-1050
Number of pages	2
Journal	Journal of the Chemical Society, Dalton Transactions
Issue number	5
DOIs	https://doi.org/10.1039/DT9860001049
State	Published - 1986

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1039/DT9860001049

Cite this

@article{ae897cf8ba604164aa862ffad17ececb,

title = "Notes. Complexation of gold(I) thiomalate ('myocrisin') with 1,3-diazinane-2-thione in aqueous solution followed by 13C nuclear magnetic resonance spectroscopy",

abstract = "The interaction of gold(I) thiomalate ('Myocrisin'; an anti-arthritic drug) [Au(tm)] with 1,3-diazinane-2-thione (L) has been studied in aqueous solution at pH * 7.2 by using 13C n.m.r. spectroscopy. It is found that [Au(tm)] forms a 1:1 complex of tm-Au-L. In the presence of excess thiomalate, L is displaced as a free ligand in solution suggesting that a thiol binds to gold(I) more strongly than does a thione.",

author = "Isab, \{Anvarhusein A.\}",

year = "1986",

doi = "10.1039/DT9860001049",

language = "English",

pages = "1049--1050",

journal = "Journal of the Chemical Society, Dalton Transactions",

issn = "1472-7773",

publisher = "Royal Society of Chemistry",

number = "5",

}

TY - JOUR

T1 - Notes. Complexation of gold(I) thiomalate ('myocrisin') with 1,3-diazinane-2-thione in aqueous solution followed by 13C nuclear magnetic resonance spectroscopy

AU - Isab, Anvarhusein A.

PY - 1986

Y1 - 1986

N2 - The interaction of gold(I) thiomalate ('Myocrisin'; an anti-arthritic drug) [Au(tm)] with 1,3-diazinane-2-thione (L) has been studied in aqueous solution at pH * 7.2 by using 13C n.m.r. spectroscopy. It is found that [Au(tm)] forms a 1:1 complex of tm-Au-L. In the presence of excess thiomalate, L is displaced as a free ligand in solution suggesting that a thiol binds to gold(I) more strongly than does a thione.

AB - The interaction of gold(I) thiomalate ('Myocrisin'; an anti-arthritic drug) [Au(tm)] with 1,3-diazinane-2-thione (L) has been studied in aqueous solution at pH * 7.2 by using 13C n.m.r. spectroscopy. It is found that [Au(tm)] forms a 1:1 complex of tm-Au-L. In the presence of excess thiomalate, L is displaced as a free ligand in solution suggesting that a thiol binds to gold(I) more strongly than does a thione.

UR - https://www.scopus.com/pages/publications/37049086565

U2 - 10.1039/DT9860001049

DO - 10.1039/DT9860001049

M3 - Article

AN - SCOPUS:37049086565

SN - 1472-7773

SP - 1049

EP - 1050

JO - Journal of the Chemical Society, Dalton Transactions

JF - Journal of the Chemical Society, Dalton Transactions

IS - 5