New conjugated dienamides via palladium-catalyzed selective aminocarbonylation of enynes

New conjugated dienamides have been synthesized effectively via palladium-catalyzed aminocarbonylation of enynes in the presence of various amines, diaminoalkanes, and aminoalcohols. The products have been utilized as substrates in alkoxycarbonylation reactions using methanol as the nucleophile and Pd(PPh ₃) ₂Cl ₂ as the catalyst to afford novel ω-amidoesters in high yields and selectivities. Interestingly, the product obtained from the alkoxycarbonylation reaction of the dienamide product of enyne 1b was observed to undergo carbonylation of the α,β-double bond with respect to the carbonyl group and isomerization of the second isolated double bond.