Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment

Hongmin Chen; Geoffrey D. Wang; Yen Jun Chuang; Zipeng Zhen; Xiaoyuan Chen; Paul Biddinger; Zhonglin Hao; Feng Liu; Baozhong Shen; Zhengwei Pan; Jin Xie

doi:10.1021/nl504044p

Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment

Hongmin Chen
, Geoffrey D. Wang
, Yen Jun Chuang
, Zipeng Zhen
, Xiaoyuan Chen
, Paul Biddinger
, Zhonglin Hao
, Feng Liu
, Baozhong Shen
, Zhengwei Pan
, Jin Xie^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

361 Scopus citations

Abstract

Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

Original language	English
Pages (from-to)	2249-2256
Number of pages	8
Journal	Nano Letters
Volume	15
Issue number	4
DOIs	https://doi.org/10.1021/nl504044p
State	Published - 8 Apr 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

X-PDT
cancer treatment
nanomedicine
nanoscintillator
radioluminescence nanophosphors
singlet oxygen

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl504044p

Cite this

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title = "Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment",

abstract = "Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.",

keywords = "X-PDT, cancer treatment, nanomedicine, nanoscintillator, radioluminescence nanophosphors, singlet oxygen",

author = "Hongmin Chen and Wang, \{Geoffrey D.\} and Chuang, \{Yen Jun\} and Zipeng Zhen and Xiaoyuan Chen and Paul Biddinger and Zhonglin Hao and Feng Liu and Baozhong Shen and Zhengwei Pan and Jin Xie",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = apr,

day = "8",

doi = "10.1021/nl504044p",

language = "English",

volume = "15",

pages = "2249--2256",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment

AU - Chen, Hongmin

AU - Wang, Geoffrey D.

AU - Chuang, Yen Jun

AU - Zhen, Zipeng

AU - Chen, Xiaoyuan

AU - Biddinger, Paul

AU - Hao, Zhonglin

AU - Liu, Feng

AU - Shen, Baozhong

AU - Pan, Zhengwei

AU - Xie, Jin

PY - 2015/4/8

Y1 - 2015/4/8

N2 - Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

AB - Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

KW - X-PDT

KW - cancer treatment

KW - nanomedicine

KW - nanoscintillator

KW - radioluminescence nanophosphors

KW - singlet oxygen

UR - https://www.scopus.com/pages/publications/84926617163

U2 - 10.1021/nl504044p

DO - 10.1021/nl504044p

M3 - Article

C2 - 25756781

AN - SCOPUS:84926617163

SN - 1530-6984

VL - 15

SP - 2249

EP - 2256

JO - Nano Letters

JF - Nano Letters

IS - 4

ER -

Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

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