Multi-photon imaging of amine-functionalized silica nanoparticles

Filipe Natalio; Anubha Kashyap; Steffen Lorenz; Hannes Kerschbaumer; Michael Dietzsch; Muhammad Nawaz Tahir; Heinz Duschner; Susanne Strand; Dennis Strand; Wolfgang Tremel

doi:10.1039/c2nr30660c

Multi-photon imaging of amine-functionalized silica nanoparticles

Filipe Natalio, Anubha Kashyap, Steffen Lorenz, Hannes Kerschbaumer, Michael Dietzsch, Muhammad Nawaz Tahir, Heinz Duschner, Susanne Strand, Dennis Strand, Wolfgang Tremel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot™ CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e.g. with antibodies, proteins) in a single step for converting these photoluminescent SiO₂ nanoparticles into multifunctional efficient vehicles for theragnostics.

Original language	English
Pages (from-to)	4680-4686
Number of pages	7
Journal	Nanoscale
Volume	4
Issue number	15
DOIs	https://doi.org/10.1039/c2nr30660c
State	Published - 7 Aug 2012
Externally published	Yes

ASJC Scopus subject areas

General Materials Science

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title = "Multi-photon imaging of amine-functionalized silica nanoparticles",

abstract = "A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot{\texttrademark} CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e.g. with antibodies, proteins) in a single step for converting these photoluminescent SiO2 nanoparticles into multifunctional efficient vehicles for theragnostics.",

author = "Filipe Natalio and Anubha Kashyap and Steffen Lorenz and Hannes Kerschbaumer and Michael Dietzsch and Tahir, \{Muhammad Nawaz\} and Heinz Duschner and Susanne Strand and Dennis Strand and Wolfgang Tremel",

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doi = "10.1039/c2nr30660c",

language = "English",

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T1 - Multi-photon imaging of amine-functionalized silica nanoparticles

AU - Natalio, Filipe

AU - Kashyap, Anubha

AU - Lorenz, Steffen

AU - Kerschbaumer, Hannes

AU - Dietzsch, Michael

AU - Tahir, Muhammad Nawaz

AU - Duschner, Heinz

AU - Strand, Susanne

AU - Strand, Dennis

AU - Tremel, Wolfgang

PY - 2012/8/7

Y1 - 2012/8/7

N2 - A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot™ CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e.g. with antibodies, proteins) in a single step for converting these photoluminescent SiO2 nanoparticles into multifunctional efficient vehicles for theragnostics.

AB - A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot™ CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e.g. with antibodies, proteins) in a single step for converting these photoluminescent SiO2 nanoparticles into multifunctional efficient vehicles for theragnostics.

UR - https://www.scopus.com/pages/publications/84863927316

U2 - 10.1039/c2nr30660c

DO - 10.1039/c2nr30660c

M3 - Article

C2 - 22735108

AN - SCOPUS:84863927316

SN - 2040-3364

VL - 4

SP - 4680

EP - 4686

JO - Nanoscale

JF - Nanoscale

IS - 15

ER -

Multi-photon imaging of amine-functionalized silica nanoparticles

Abstract

ASJC Scopus subject areas

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