Abstract
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumor necrosis factor (TNF) family ligand that binds on the death receptors, DR4 and DR5, activating apoptotic pathways selectively in cancer cells and thus has become a promising cancer therapeutic agent. Compound 1, isolated from Streptomyces sp. IFM 10937, has shown activity in overcoming TRAIL resistance in AGS cells. Synthesis of 1 has been accomplished from L-tyrosine in an overall high-yielding reaction sequence. GRAPHICAL ABSTRACT.
| Original language | English |
|---|---|
| Pages (from-to) | 599-604 |
| Number of pages | 6 |
| Journal | Synthetic Communications |
| Volume | 45 |
| Issue number | 5 |
| DOIs | |
| State | Published - 4 Mar 2015 |
Bibliographical note
Publisher Copyright:Copyright © 2015 Taylor & Francis Group, LLC.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer
- TRAIL
- olefin cross-metathesis reaction
- total synthesis
- tyrosine derivative
ASJC Scopus subject areas
- Organic Chemistry
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