Microwave-Assisted Claisen Rearrangement: Synthesis of Naturally Occurring TRAIL-Resistance-Overcoming Tyrosine Derivative

M. Mansha; Y. Abbas; N. Ullah

doi:10.1080/00397911.2014.974614

Microwave-Assisted Claisen Rearrangement: Synthesis of Naturally Occurring TRAIL-Resistance-Overcoming Tyrosine Derivative

M. Mansha, Y. Abbas, N. Ullah^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumor necrosis factor (TNF) family ligand that binds on the death receptors, DR4 and DR5, activating apoptotic pathways selectively in cancer cells and thus has become a promising cancer therapeutic agent. Compound 1, isolated from Streptomyces sp. IFM 10937, has shown activity in overcoming TRAIL resistance in AGS cells. Synthesis of 1 has been accomplished from L-tyrosine in an overall high-yielding reaction sequence. GRAPHICAL ABSTRACT.

Original language	English
Pages (from-to)	599-604
Number of pages	6
Journal	Synthetic Communications
Volume	45
Issue number	5
DOIs	https://doi.org/10.1080/00397911.2014.974614
State	Published - 4 Mar 2015

Bibliographical note

Publisher Copyright:
Copyright © 2015 Taylor & Francis Group, LLC.

Keywords

Cancer
TRAIL
olefin cross-metathesis reaction
total synthesis
tyrosine derivative

ASJC Scopus subject areas

Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/00397911.2014.974614

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title = "Microwave-Assisted Claisen Rearrangement: Synthesis of Naturally Occurring TRAIL-Resistance-Overcoming Tyrosine Derivative",

abstract = "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumor necrosis factor (TNF) family ligand that binds on the death receptors, DR4 and DR5, activating apoptotic pathways selectively in cancer cells and thus has become a promising cancer therapeutic agent. Compound 1, isolated from Streptomyces sp. IFM 10937, has shown activity in overcoming TRAIL resistance in AGS cells. Synthesis of 1 has been accomplished from L-tyrosine in an overall high-yielding reaction sequence. GRAPHICAL ABSTRACT.",

keywords = "Cancer, TRAIL, olefin cross-metathesis reaction, total synthesis, tyrosine derivative",

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AU - Abbas, Y.

AU - Ullah, N.

PY - 2015/3/4

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AB - Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumor necrosis factor (TNF) family ligand that binds on the death receptors, DR4 and DR5, activating apoptotic pathways selectively in cancer cells and thus has become a promising cancer therapeutic agent. Compound 1, isolated from Streptomyces sp. IFM 10937, has shown activity in overcoming TRAIL resistance in AGS cells. Synthesis of 1 has been accomplished from L-tyrosine in an overall high-yielding reaction sequence. GRAPHICAL ABSTRACT.

KW - Cancer

KW - TRAIL

KW - olefin cross-metathesis reaction

KW - total synthesis

KW - tyrosine derivative

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JO - Synthetic Communications

JF - Synthetic Communications

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ER -

Microwave-Assisted Claisen Rearrangement: Synthesis of Naturally Occurring TRAIL-Resistance-Overcoming Tyrosine Derivative

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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