Microfluidic-assisted self-assembly of complex dendritic polyethylene drug delivery nanocapsules

Mohammad Mahdi Hasani-Sadrabadi; Vahid Karimkhani; Fatemeh Sadat Majedi; Jules John Van Dersarl; Erfan Dashtimoghadam; Faramarz Afshar-Taromi; Hamid Mirzadeh; Arnaud Bertsch; Karl I. Jacob; Philippe Renaud; Florian J. Stadler; Il Kim

doi:10.1002/adma.201305753

Microfluidic-assisted self-assembly of complex dendritic polyethylene drug delivery nanocapsules

Mohammad Mahdi Hasani-Sadrabadi
, Vahid Karimkhani
, Fatemeh Sadat Majedi
, Jules John Van Dersarl
, Erfan Dashtimoghadam
, Faramarz Afshar-Taromi
, Hamid Mirzadeh
, Arnaud Bertsch
, Karl I. Jacob^*
, Philippe Renaud
, Florian J. Stadler
, Il Kim

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Microfluidic platform for the synthesis of complex nanocapsules is presented via a controlled self-assembly. The monodisperse nanocapsules in the range of 50-200 nm consist of a dendritic polyethylene core and a Pluronic copolymer shell. The resultant nanocarriers encapsulate large amount of hydrophobic anticancer drug like paclitaxel while providing a low complement activation as well as sustained release profile with high tunability.

Original language	English
Pages (from-to)	3118-3123
Number of pages	6
Journal	Advanced Materials
Volume	26
Issue number	19
DOIs	https://doi.org/10.1002/adma.201305753
State	Published - 21 May 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer therapeutics
controlled drug delivery
hyperbranched polyethylene nanocapsule
microfluidic-assisted self-assembly
paclitaxel

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1002/adma.201305753

Cite this

Hasani-Sadrabadi, M. M., Karimkhani, V., Majedi, F. S., Van Dersarl, J. J., Dashtimoghadam, E., Afshar-Taromi, F., Mirzadeh, H., Bertsch, A., Jacob, K. I., Renaud, P., Stadler, F. J., & Kim, I. (2014). Microfluidic-assisted self-assembly of complex dendritic polyethylene drug delivery nanocapsules. Advanced Materials, 26(19), 3118-3123. https://doi.org/10.1002/adma.201305753

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abstract = "Microfluidic platform for the synthesis of complex nanocapsules is presented via a controlled self-assembly. The monodisperse nanocapsules in the range of 50-200 nm consist of a dendritic polyethylene core and a Pluronic copolymer shell. The resultant nanocarriers encapsulate large amount of hydrophobic anticancer drug like paclitaxel while providing a low complement activation as well as sustained release profile with high tunability.",

keywords = "cancer therapeutics, controlled drug delivery, hyperbranched polyethylene nanocapsule, microfluidic-assisted self-assembly, paclitaxel",

author = "Hasani-Sadrabadi, \{Mohammad Mahdi\} and Vahid Karimkhani and Majedi, \{Fatemeh Sadat\} and \{Van Dersarl\}, \{Jules John\} and Erfan Dashtimoghadam and Faramarz Afshar-Taromi and Hamid Mirzadeh and Arnaud Bertsch and Jacob, \{Karl I.\} and Philippe Renaud and Stadler, \{Florian J.\} and Il Kim",

year = "2014",

month = may,

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doi = "10.1002/adma.201305753",

language = "English",

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T1 - Microfluidic-assisted self-assembly of complex dendritic polyethylene drug delivery nanocapsules

AU - Hasani-Sadrabadi, Mohammad Mahdi

AU - Karimkhani, Vahid

AU - Majedi, Fatemeh Sadat

AU - Van Dersarl, Jules John

AU - Dashtimoghadam, Erfan

AU - Afshar-Taromi, Faramarz

AU - Mirzadeh, Hamid

AU - Bertsch, Arnaud

AU - Jacob, Karl I.

AU - Renaud, Philippe

AU - Stadler, Florian J.

AU - Kim, Il

PY - 2014/5/21

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N2 - Microfluidic platform for the synthesis of complex nanocapsules is presented via a controlled self-assembly. The monodisperse nanocapsules in the range of 50-200 nm consist of a dendritic polyethylene core and a Pluronic copolymer shell. The resultant nanocarriers encapsulate large amount of hydrophobic anticancer drug like paclitaxel while providing a low complement activation as well as sustained release profile with high tunability.

AB - Microfluidic platform for the synthesis of complex nanocapsules is presented via a controlled self-assembly. The monodisperse nanocapsules in the range of 50-200 nm consist of a dendritic polyethylene core and a Pluronic copolymer shell. The resultant nanocarriers encapsulate large amount of hydrophobic anticancer drug like paclitaxel while providing a low complement activation as well as sustained release profile with high tunability.

KW - cancer therapeutics

KW - controlled drug delivery

KW - hyperbranched polyethylene nanocapsule

KW - microfluidic-assisted self-assembly

KW - paclitaxel

UR - https://www.scopus.com/pages/publications/84901052911

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DO - 10.1002/adma.201305753

M3 - Article

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JO - Advanced Materials

JF - Advanced Materials

IS - 19

ER -

Microfluidic-assisted self-assembly of complex dendritic polyethylene drug delivery nanocapsules

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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