Microfibers fabricated by non-covalent assembly of peptide and DNA for viral vector encapsulation and cancer therapy

Jingye Yang; Ghayathri Balasundaram; Seong Loong Lo; Eugene Choo Shi Guang; Jun Min Xue; Jianxing Song; Andrew C.A. Wan; Jackie Y. Ying; Shu Wang

doi:10.1002/adma.201201145

Microfibers fabricated by non-covalent assembly of peptide and DNA for viral vector encapsulation and cancer therapy

Jingye Yang, Ghayathri Balasundaram, Seong Loong Lo, Eugene Choo Shi Guang, Jun Min Xue, Jianxing Song, Andrew C.A. Wan, Jackie Y. Ying, Shu Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Self-assembled amphiphilic peptide units and supercoiled, circular double-stranded plasmid DNA are used as building blocks to form peptide/DNA fibers for virus encapsulation. Since the fiber formation process takes place under ambient conditions and is aqueous-based without the use of denaturing organic solvents, the bioactivity of viruses is well preserved.

Original language	English
Pages (from-to)	3280-3284
Number of pages	5
Journal	Advanced Materials
Volume	24
Issue number	24
DOIs	https://doi.org/10.1002/adma.201201145
State	Published - 26 Jun 2012
Externally published	Yes

Keywords

DNA
biomolecular materials
cancer therapy
peptide
virus encapsulation

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adma.201201145

Cite this

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title = "Microfibers fabricated by non-covalent assembly of peptide and DNA for viral vector encapsulation and cancer therapy",

abstract = "Self-assembled amphiphilic peptide units and supercoiled, circular double-stranded plasmid DNA are used as building blocks to form peptide/DNA fibers for virus encapsulation. Since the fiber formation process takes place under ambient conditions and is aqueous-based without the use of denaturing organic solvents, the bioactivity of viruses is well preserved.",

keywords = "DNA, biomolecular materials, cancer therapy, peptide, virus encapsulation",

author = "Jingye Yang and Ghayathri Balasundaram and Lo, \{Seong Loong\} and Guang, \{Eugene Choo Shi\} and Xue, \{Jun Min\} and Jianxing Song and Wan, \{Andrew C.A.\} and Ying, \{Jackie Y.\} and Shu Wang",

year = "2012",

month = jun,

day = "26",

doi = "10.1002/adma.201201145",

language = "English",

volume = "24",

pages = "3280--3284",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

number = "24",

}

TY - JOUR

T1 - Microfibers fabricated by non-covalent assembly of peptide and DNA for viral vector encapsulation and cancer therapy

AU - Yang, Jingye

AU - Balasundaram, Ghayathri

AU - Lo, Seong Loong

AU - Guang, Eugene Choo Shi

AU - Xue, Jun Min

AU - Song, Jianxing

AU - Wan, Andrew C.A.

AU - Ying, Jackie Y.

AU - Wang, Shu

PY - 2012/6/26

Y1 - 2012/6/26

N2 - Self-assembled amphiphilic peptide units and supercoiled, circular double-stranded plasmid DNA are used as building blocks to form peptide/DNA fibers for virus encapsulation. Since the fiber formation process takes place under ambient conditions and is aqueous-based without the use of denaturing organic solvents, the bioactivity of viruses is well preserved.

AB - Self-assembled amphiphilic peptide units and supercoiled, circular double-stranded plasmid DNA are used as building blocks to form peptide/DNA fibers for virus encapsulation. Since the fiber formation process takes place under ambient conditions and is aqueous-based without the use of denaturing organic solvents, the bioactivity of viruses is well preserved.

KW - DNA

KW - biomolecular materials

KW - cancer therapy

KW - peptide

KW - virus encapsulation

UR - https://www.scopus.com/pages/publications/84862583461

U2 - 10.1002/adma.201201145

DO - 10.1002/adma.201201145

M3 - Article

C2 - 22628070

AN - SCOPUS:84862583461

SN - 0935-9648

VL - 24

SP - 3280

EP - 3284

JO - Advanced Materials

JF - Advanced Materials

IS - 24

ER -

Microfibers fabricated by non-covalent assembly of peptide and DNA for viral vector encapsulation and cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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