Abstract
A reversible and cyclic magnetic-field stimulated DNA oxidation is described. Positioning an external magnet below the electrode attracts the DNA-functionalized magnetic particles to the surface, and stimulates the oxidation of the guanine nucleobases. Using a dual carbon-paste electrode assembly we demonstrate a spatially controlled DNA oxidation, with an 'ON/OFF' switching of the electron-transfer reaction upon relocating the external magnetic field. The process can be reversed and repeated upon switching the position of the magnet, with and without oxidation signals in the presence and absence of the magnetic field, respectively. We also demonstrate a 'magnetic' carbon-paste electrode, with an internal magnet, that collects the DNA-modified beads and stimulates the DNA oxidation process. The site-specific activation of the DNA oxidation holds promise for new DNA arrays and other geno-electronic applications.
| Original language | English |
|---|---|
| Pages (from-to) | 349-352 |
| Number of pages | 4 |
| Journal | Electrochemistry Communications |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
Bibliographical note
Funding Information:This research was supported by grants from NIH (Grant No. R01 14549-02) and the US Army Medical Research (Award No. DAMD17-00-1-0366). A fellowship from the Egyptian government (to AK) is acknowledged.
Keywords
- Carbon-paste electrode
- DNA
- Guanine oxidation
- Magnet
ASJC Scopus subject areas
- Electrochemistry
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