Abstract
This article presents low-frequency shift Raman spectroscopy of pharmaceutical respirable powders. We show that acquisition of this type of Raman spectra is possible with appropriate instrument design and choice of optics for Rayleigh scattering rejection, enabling low wavenumber diagnostic bands to be observed. Our Raman spectra show unique spectral signatures for discriminating between different polymorphs of mannitol, and amorphous and crystalline forms of glycopyrronium bromide. In addition, we present a deconvolution method to quantify fluticasone propionate in three commercial pharmaceutical respirable powders.
| Original language | English |
|---|---|
| Pages | 27-33 |
| Number of pages | 7 |
| Volume | 20 |
| No | 5 |
| Specialist publication | European Pharmaceutical Review |
| State | Published - 2015 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 Russell Publishing Limited.
ASJC Scopus subject areas
- Biotechnology
- Biophysics
- Biochemistry
- Molecular Medicine
- General Pharmacology, Toxicology and Pharmaceutics
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