Kinetic determination of propranolol in tablets by oxidation with ceric sulphate

Salah M. Sultan; Saad A. Altamrah; Abdullah M. Aziz Alrahman; Ibrahim Z. Alzamil; Mohammed O. Karrar

doi:10.1016/0731-7085(89)80094-9

Kinetic determination of propranolol in tablets by oxidation with ceric sulphate

Salah M. Sultan^*, Saad A. Altamrah, Abdullah M. Aziz Alrahman, Ibrahim Z. Alzamil, Mohammed O. Karrar

^*Corresponding author for this work

King Fahd University of Petroleum & Minerals

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A simple and accurate kinetic method for the determination of propranolol has been developed. Cerium(IV) sulphate (0.5 M) is used to oxidize propranolol in 2 M sulphuric acid at room temperature to the ketone form that absorbs light at a λ_max of 525 nm. The fixed-concentration method is used by recording the exact time, t(s), taken for the reaction to reach a fixed absorbance of 0.100. The unknown concentration, c(M), of propranolol is calculated from the equation: 1/t = 0 0.000217 + 0.03 c. The method has been applied to the determination of propranolol in proprietary tablets and the results were compared with those obtained by the B.P. and other standard methods.

Original language	English
Pages (from-to)	279-286
Number of pages	8
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/0731-7085(89)80094-9
State	Published - 1989

Keywords

Kinetics
fixed-absorbance method
propranolol determination.

ASJC Scopus subject areas

Analytical Chemistry
Pharmaceutical Science
Drug Discovery
Spectroscopy
Clinical Biochemistry

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10.1016/0731-7085(89)80094-9

Cite this

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title = "Kinetic determination of propranolol in tablets by oxidation with ceric sulphate",

abstract = "A simple and accurate kinetic method for the determination of propranolol has been developed. Cerium(IV) sulphate (0.5 M) is used to oxidize propranolol in 2 M sulphuric acid at room temperature to the ketone form that absorbs light at a λmax of 525 nm. The fixed-concentration method is used by recording the exact time, t(s), taken for the reaction to reach a fixed absorbance of 0.100. The unknown concentration, c(M), of propranolol is calculated from the equation: 1/t = 0 0.000217 + 0.03 c. The method has been applied to the determination of propranolol in proprietary tablets and the results were compared with those obtained by the B.P. and other standard methods.",

keywords = "Kinetics, fixed-absorbance method, propranolol determination.",

author = "Sultan, \{Salah M.\} and Altamrah, \{Saad A.\} and \{Aziz Alrahman\}, \{Abdullah M.\} and Alzamil, \{Ibrahim Z.\} and Karrar, \{Mohammed O.\}",

year = "1989",

doi = "10.1016/0731-7085(89)80094-9",

language = "English",

volume = "7",

pages = "279--286",

journal = "Journal of Pharmaceutical and Biomedical Analysis",

issn = "0731-7085",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Kinetic determination of propranolol in tablets by oxidation with ceric sulphate

AU - Sultan, Salah M.

AU - Altamrah, Saad A.

AU - Aziz Alrahman, Abdullah M.

AU - Alzamil, Ibrahim Z.

AU - Karrar, Mohammed O.

PY - 1989

Y1 - 1989

N2 - A simple and accurate kinetic method for the determination of propranolol has been developed. Cerium(IV) sulphate (0.5 M) is used to oxidize propranolol in 2 M sulphuric acid at room temperature to the ketone form that absorbs light at a λmax of 525 nm. The fixed-concentration method is used by recording the exact time, t(s), taken for the reaction to reach a fixed absorbance of 0.100. The unknown concentration, c(M), of propranolol is calculated from the equation: 1/t = 0 0.000217 + 0.03 c. The method has been applied to the determination of propranolol in proprietary tablets and the results were compared with those obtained by the B.P. and other standard methods.

AB - A simple and accurate kinetic method for the determination of propranolol has been developed. Cerium(IV) sulphate (0.5 M) is used to oxidize propranolol in 2 M sulphuric acid at room temperature to the ketone form that absorbs light at a λmax of 525 nm. The fixed-concentration method is used by recording the exact time, t(s), taken for the reaction to reach a fixed absorbance of 0.100. The unknown concentration, c(M), of propranolol is calculated from the equation: 1/t = 0 0.000217 + 0.03 c. The method has been applied to the determination of propranolol in proprietary tablets and the results were compared with those obtained by the B.P. and other standard methods.

KW - Kinetics

KW - fixed-absorbance method

KW - propranolol determination.

UR - https://www.scopus.com/pages/publications/0024476102

U2 - 10.1016/0731-7085(89)80094-9

DO - 10.1016/0731-7085(89)80094-9

M3 - Article

C2 - 2488628

AN - SCOPUS:0024476102

SN - 0731-7085

VL - 7

SP - 279

EP - 286

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

IS - 3

ER -

Kinetic determination of propranolol in tablets by oxidation with ceric sulphate

Abstract

Keywords

ASJC Scopus subject areas

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