Isoelectronic Pt(ii)- and Au(iii)-N-heterocyclic carbene complexes: A structural and biological comparison

Bidyut Kumar Rana; Snehasis Mishra; Deblina Sarkar; Tapan Kumar Mondal; Saikat K. Seth; Valerio Bertolasi; Krishna Das Saha; Christopher W. Bielawski; Anvarhusein A. Isab; Joydev Dinda

doi:10.1039/c8nj01562g

Isoelectronic Pt(ii)- and Au(iii)-N-heterocyclic carbene complexes: A structural and biological comparison

Bidyut Kumar Rana
, Snehasis Mishra
, Deblina Sarkar
, Tapan Kumar Mondal
, Saikat K. Seth
, Valerio Bertolasi
, Krishna Das Saha
, Christopher W. Bielawski
, Anvarhusein A. Isab
, Joydev Dinda^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

To elucidate the intrinsic biological activities displayed by platinum versus gold-based organometallic reagents, the isoelectronic and isostructural square planar complexes [Pt(C∩N)(C)Cl][PF₆] (2) and [Au(C∩N)(C)Cl][PF₆]₂ (3), which are supported by a common N-heterocyclic carbene, 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylidene (1), were synthesized. The complexes were characterized using a range of spectroscopic techniques as well as single crystal X-ray diffraction and a series of computational studies were also performed to gain additional insight into their fundamental electronic bonding structures. The cytotoxicities of the complexes were tested in vitro against non-small lung carcinoma (A549), colorectal carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines. The measured IC₅₀ values showed that the Au(iii)-NHC complex is more potent than its Pt analogue.

Original language	English
Pages (from-to)	10704-10711
Number of pages	8
Journal	New Journal of Chemistry
Volume	42
Issue number	13
DOIs	https://doi.org/10.1039/c8nj01562g
State	Published - 2018

Bibliographical note

Publisher Copyright:
© 2018 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

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ASJC Scopus subject areas

Catalysis
General Chemistry
Materials Chemistry

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@article{b7202dedd4054c4394dfd3c6469a923e,

title = "Isoelectronic Pt(ii)- and Au(iii)-N-heterocyclic carbene complexes: A structural and biological comparison",

abstract = "To elucidate the intrinsic biological activities displayed by platinum versus gold-based organometallic reagents, the isoelectronic and isostructural square planar complexes [Pt(C∩N)(C)Cl][PF6] (2) and [Au(C∩N)(C)Cl][PF6]2 (3), which are supported by a common N-heterocyclic carbene, 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylidene (1), were synthesized. The complexes were characterized using a range of spectroscopic techniques as well as single crystal X-ray diffraction and a series of computational studies were also performed to gain additional insight into their fundamental electronic bonding structures. The cytotoxicities of the complexes were tested in vitro against non-small lung carcinoma (A549), colorectal carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines. The measured IC50 values showed that the Au(iii)-NHC complex is more potent than its Pt analogue.",

author = "Rana, \{Bidyut Kumar\} and Snehasis Mishra and Deblina Sarkar and Mondal, \{Tapan Kumar\} and Seth, \{Saikat K.\} and Valerio Bertolasi and \{Das Saha\}, Krishna and Bielawski, \{Christopher W.\} and Isab, \{Anvarhusein A.\} and Joydev Dinda",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.",

year = "2018",

doi = "10.1039/c8nj01562g",

language = "English",

volume = "42",

pages = "10704--10711",

journal = "New Journal of Chemistry",

issn = "1144-0546",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Isoelectronic Pt(ii)- and Au(iii)-N-heterocyclic carbene complexes

T2 - A structural and biological comparison

AU - Rana, Bidyut Kumar

AU - Mishra, Snehasis

AU - Sarkar, Deblina

AU - Mondal, Tapan Kumar

AU - Seth, Saikat K.

AU - Bertolasi, Valerio

AU - Das Saha, Krishna

AU - Bielawski, Christopher W.

AU - Isab, Anvarhusein A.

AU - Dinda, Joydev

PY - 2018

Y1 - 2018

N2 - To elucidate the intrinsic biological activities displayed by platinum versus gold-based organometallic reagents, the isoelectronic and isostructural square planar complexes [Pt(C∩N)(C)Cl][PF6] (2) and [Au(C∩N)(C)Cl][PF6]2 (3), which are supported by a common N-heterocyclic carbene, 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylidene (1), were synthesized. The complexes were characterized using a range of spectroscopic techniques as well as single crystal X-ray diffraction and a series of computational studies were also performed to gain additional insight into their fundamental electronic bonding structures. The cytotoxicities of the complexes were tested in vitro against non-small lung carcinoma (A549), colorectal carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines. The measured IC50 values showed that the Au(iii)-NHC complex is more potent than its Pt analogue.

AB - To elucidate the intrinsic biological activities displayed by platinum versus gold-based organometallic reagents, the isoelectronic and isostructural square planar complexes [Pt(C∩N)(C)Cl][PF6] (2) and [Au(C∩N)(C)Cl][PF6]2 (3), which are supported by a common N-heterocyclic carbene, 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylidene (1), were synthesized. The complexes were characterized using a range of spectroscopic techniques as well as single crystal X-ray diffraction and a series of computational studies were also performed to gain additional insight into their fundamental electronic bonding structures. The cytotoxicities of the complexes were tested in vitro against non-small lung carcinoma (A549), colorectal carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines. The measured IC50 values showed that the Au(iii)-NHC complex is more potent than its Pt analogue.

UR - https://www.scopus.com/pages/publications/85049165130

U2 - 10.1039/c8nj01562g

DO - 10.1039/c8nj01562g

M3 - Article

AN - SCOPUS:85049165130

SN - 1144-0546

VL - 42

SP - 10704

EP - 10711

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 13

ER -

Isoelectronic Pt(ii)- and Au(iii)-N-heterocyclic carbene complexes: A structural and biological comparison

Abstract

Bibliographical note

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