Interpreting artificial intelligence models: a systematic review on the application of LIME and SHAP in Alzheimer’s disease detection

Viswan Vimbi, Noushath Shaffi, Mufti Mahmud*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Explainable artificial intelligence (XAI) has gained much interest in recent years for its ability to explain the complex decision-making process of machine learning (ML) and deep learning (DL) models. The Local Interpretable Model-agnostic Explanations (LIME) and Shaply Additive exPlanation (SHAP) frameworks have grown as popular interpretive tools for ML and DL models. This article provides a systematic review of the application of LIME and SHAP in interpreting the detection of Alzheimer’s disease (AD). Adhering to PRISMA and Kitchenham’s guidelines, we identified 23 relevant articles and investigated these frameworks’ prospective capabilities, benefits, and challenges in depth. The results emphasise XAI’s crucial role in strengthening the trustworthiness of AI-based AD predictions. This review aims to provide fundamental capabilities of LIME and SHAP XAI frameworks in enhancing fidelity within clinical decision support systems for AD prognosis.

Original languageEnglish
Article number10
JournalBrain Informatics
Volume11
Issue number1
DOIs
StatePublished - Dec 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

Keywords

  • Explainable artificial intelligence
  • LIME
  • Model agnostic
  • Model specific
  • Post-hoc anti-hoc
  • SHAP

ASJC Scopus subject areas

  • Neurology
  • Computer Science Applications
  • Cognitive Neuroscience

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