In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor

Chad Sager; Philip LeDuc; Taher Saif

doi:10.1109/MMB.2000.893745

In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor

Chad Sager
, Philip LeDuc
, Taher Saif

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

Although previous studies of the adhesion properties of single living cells have been conducted a full understanding has still not been attained. In this article a MEMS sensor has been employed to study, quantitatively and qualitatively, the adhesion properties of a single living bovine endothelial cell. The strength of a single focal adhesion site to an extracellular matrix coated substrate is found to be 37 nN. Focal adhesion sites have been observed, insitu, to be spaced on the order of 1 μm intervals. A model is also proposed to describe the mechanism of detachment of a single living cell from a substrate.

Original language	English
Title of host publication	1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
Editors	Andre Dittmar, David Beebe
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	76-79
Number of pages	4
ISBN (Electronic)	0780366034, 9780780366039
DOIs	https://doi.org/10.1109/MMB.2000.893745
State	Published - 2000
Externally published	Yes
Event	1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000 - Lyon, France Duration: 12 Oct 2000 → 14 Oct 2000

Publication series

Name	1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings

Conference

Conference	1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000
Country/Territory	France
City	Lyon
Period	12/10/00 → 14/10/00

Bibliographical note

Publisher Copyright:
© 2000 IEEE.

ASJC Scopus subject areas

General Engineering

Access to Document

10.1109/MMB.2000.893745

Cite this

Sager, C., LeDuc, P., & Saif, T. (2000). In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor. In A. Dittmar, & D. Beebe (Eds.), 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings (pp. 76-79). Article 893745 (1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MMB.2000.893745

Sager, Chad ; LeDuc, Philip ; Saif, Taher. / In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor. 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings. editor / Andre Dittmar ; David Beebe. Institute of Electrical and Electronics Engineers Inc., 2000. pp. 76-79 (1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings).

@inproceedings{2b8496dcd9124dd1a61cc54eb6a7fb56,

title = "In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor",

abstract = "Although previous studies of the adhesion properties of single living cells have been conducted a full understanding has still not been attained. In this article a MEMS sensor has been employed to study, quantitatively and qualitatively, the adhesion properties of a single living bovine endothelial cell. The strength of a single focal adhesion site to an extracellular matrix coated substrate is found to be 37 nN. Focal adhesion sites have been observed, insitu, to be spaced on the order of 1 μm intervals. A model is also proposed to describe the mechanism of detachment of a single living cell from a substrate.",

author = "Chad Sager and Philip LeDuc and Taher Saif",

note = "Publisher Copyright: {\textcopyright} 2000 IEEE.; 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000 ; Conference date: 12-10-2000 Through 14-10-2000",

year = "2000",

doi = "10.1109/MMB.2000.893745",

language = "English",

series = "1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "76--79",

editor = "Andre Dittmar and David Beebe",

booktitle = "1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings",

address = "United States",

}

Sager, C, LeDuc, P & Saif, T 2000, In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor. in A Dittmar & D Beebe (eds), 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings., 893745, 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings, Institute of Electrical and Electronics Engineers Inc., pp. 76-79, 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000, Lyon, France, 12/10/00. https://doi.org/10.1109/MMB.2000.893745

In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor. / Sager, Chad; LeDuc, Philip; Saif, Taher.
1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings. ed. / Andre Dittmar; David Beebe. Institute of Electrical and Electronics Engineers Inc., 2000. p. 76-79 893745 (1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor

AU - Sager, Chad

AU - LeDuc, Philip

AU - Saif, Taher

PY - 2000

Y1 - 2000

N2 - Although previous studies of the adhesion properties of single living cells have been conducted a full understanding has still not been attained. In this article a MEMS sensor has been employed to study, quantitatively and qualitatively, the adhesion properties of a single living bovine endothelial cell. The strength of a single focal adhesion site to an extracellular matrix coated substrate is found to be 37 nN. Focal adhesion sites have been observed, insitu, to be spaced on the order of 1 μm intervals. A model is also proposed to describe the mechanism of detachment of a single living cell from a substrate.

AB - Although previous studies of the adhesion properties of single living cells have been conducted a full understanding has still not been attained. In this article a MEMS sensor has been employed to study, quantitatively and qualitatively, the adhesion properties of a single living bovine endothelial cell. The strength of a single focal adhesion site to an extracellular matrix coated substrate is found to be 37 nN. Focal adhesion sites have been observed, insitu, to be spaced on the order of 1 μm intervals. A model is also proposed to describe the mechanism of detachment of a single living cell from a substrate.

UR - https://www.scopus.com/pages/publications/84952643464

U2 - 10.1109/MMB.2000.893745

DO - 10.1109/MMB.2000.893745

M3 - Conference contribution

AN - SCOPUS:84952643464

T3 - 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings

SP - 76

EP - 79

BT - 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings

A2 - Dittmar, Andre

A2 - Beebe, David

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000

Y2 - 12 October 2000 through 14 October 2000

ER -

Sager C, LeDuc P, Saif T. In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor. In Dittmar A, Beebe D, editors, 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2000. p. 76-79. 893745. (1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings). doi: 10.1109/MMB.2000.893745

In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor

Abstract

Publication series

Conference

Bibliographical note

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this